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Cancer chemoprevention by ginseng in mouse liver and other organs.
Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05)....
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Academy of Medical Sciences
2001
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202212/ https://www.ncbi.nlm.nih.gov/pubmed/11748379 |
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author | Nishino, H Tokuda, H Ii, T Takemura, M Kuchide, M Kanazawa, M Mou, X Y Bu, P Takayasu, J Onozuka, M Masuda, M Satomi, Y Konoshima, T Kishi, N Baba, M Okada, Y Okuyama, T |
author_facet | Nishino, H Tokuda, H Ii, T Takemura, M Kuchide, M Kanazawa, M Mou, X Y Bu, P Takayasu, J Onozuka, M Masuda, M Satomi, Y Konoshima, T Kishi, N Baba, M Okada, Y Okuyama, T |
author_sort | Nishino, H |
collection | PubMed |
description | Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention. |
format | Online Article Text |
id | pubmed-3202212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-32022122011-10-28 Cancer chemoprevention by ginseng in mouse liver and other organs. Nishino, H Tokuda, H Ii, T Takemura, M Kuchide, M Kanazawa, M Mou, X Y Bu, P Takayasu, J Onozuka, M Masuda, M Satomi, Y Konoshima, T Kishi, N Baba, M Okada, Y Okuyama, T J Korean Med Sci Research Article Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention. Korean Academy of Medical Sciences 2001-12 /pmc/articles/PMC3202212/ /pubmed/11748379 Text en |
spellingShingle | Research Article Nishino, H Tokuda, H Ii, T Takemura, M Kuchide, M Kanazawa, M Mou, X Y Bu, P Takayasu, J Onozuka, M Masuda, M Satomi, Y Konoshima, T Kishi, N Baba, M Okada, Y Okuyama, T Cancer chemoprevention by ginseng in mouse liver and other organs. |
title | Cancer chemoprevention by ginseng in mouse liver and other organs. |
title_full | Cancer chemoprevention by ginseng in mouse liver and other organs. |
title_fullStr | Cancer chemoprevention by ginseng in mouse liver and other organs. |
title_full_unstemmed | Cancer chemoprevention by ginseng in mouse liver and other organs. |
title_short | Cancer chemoprevention by ginseng in mouse liver and other organs. |
title_sort | cancer chemoprevention by ginseng in mouse liver and other organs. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202212/ https://www.ncbi.nlm.nih.gov/pubmed/11748379 |
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