Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer

Initially thought as being non-immunogenic, recombinant AAVs have emerged as efficient vector candidates for treating monogenic diseases. It is now clear however that they induce potent immune responses against transgene products which can lead to destruction of transduced cells. Therefore, developi...

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Detalles Bibliográficos
Autores principales: Adriouch, Sahil, Franck, Emilie, Drouot, Laurent, Bonneau, Carole, Jolinon, Nelly, Salvetti, Anna, Boyer, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202221/
https://www.ncbi.nlm.nih.gov/pubmed/22046170
http://dx.doi.org/10.3389/fmicb.2011.00199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202221/
https://www.ncbi.nlm.nih.gov/pubmed/22046170
http://dx.doi.org/10.3389/fmicb.2011.00199

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