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Impact of Genetic Variation in SORCS1 on Memory Retention

OBJECTIVE: We previously reported that genetic variants in SORCS1 increase the risk of AD, that over-expression of SorCS1 reduces γ-secretase activity and Aβ levels, and that SorCS1 suppression increases γ-secretase processing of APP and Aβ levels. We now explored the effect of variation in SORCS1 o...

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Detalles Bibliográficos
Autores principales:	Reitz, Christiane, Lee, Joseph H., Rogers, Robert S., Mayeux, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202519/ https://www.ncbi.nlm.nih.gov/pubmed/22046233 http://dx.doi.org/10.1371/journal.pone.0024588

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