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Recombinant TAT-CD137 Ligand Cytoplasmic Domain Fusion Protein Induces the Production of IL-6 and TNF-α in Peritoneal Macrophages

BACKGROUND: The ligand for CD137 (CD137L; also called 4-1BBL) is mainly expressed on activated APCs such as dendritic cells, B cells and macrophages. Even though CD137L functions as a trigger of the CD137 signaling pathway for T cell activation and expansion, engagement of CD137L can deliver a signa...

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Detalles Bibliográficos
Autores principales: Kim, Jung Dae, Lee, Eun Ah, Quang, Nguyen N., Cho, Hong Rae, Kwon, Byungsuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202621/
https://www.ncbi.nlm.nih.gov/pubmed/22039370
http://dx.doi.org/10.4110/in.2011.11.4.216