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Plasma membrane microdomains regulate TACE-dependent TNFR1 shedding in human endothelial cells

Upon stimulation by histamine, human vascular endothelial cells (EC) shed a soluble form of tumour necrosis factor receptor 1 (sTNFR1) that binds up free TNF, dampening the inflammatory response. Shedding occurs through proteolytic cleavage of plasma membrane-expressed TNFR1 catalysed by TNF-α conve...

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Detalles Bibliográficos
Autores principales:	D’Alessio, Alessio, Esposito, Bianca, Giampietri, Claudia, Ziparo, Elio, Pober, Jordan S, Filippini, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202671/ https://www.ncbi.nlm.nih.gov/pubmed/21645239 http://dx.doi.org/10.1111/j.1582-4934.2011.01353.x

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