Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae

Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines w...

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Detalles Bibliográficos
Autores principales: Chang, Perng-Kuang, Ehrlich, Kenneth C., Fujii, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202784/
https://www.ncbi.nlm.nih.gov/pubmed/22069533
http://dx.doi.org/10.3390/toxins1020074
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author Chang, Perng-Kuang
Ehrlich, Kenneth C.
Fujii, Isao
author_facet Chang, Perng-Kuang
Ehrlich, Kenneth C.
Fujii, Isao
author_sort Chang, Perng-Kuang
collection PubMed
description Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines what is currently known about the toxicity of CPA to animals and humans, both by itself or in combination with other mycotoxins. The review also discusses CPA biosynthesis and the genetic diversity of CPA production in A. flavus/oryzae populations.
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spelling pubmed-32027842011-11-08 Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae Chang, Perng-Kuang Ehrlich, Kenneth C. Fujii, Isao Toxins (Basel) Review Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines what is currently known about the toxicity of CPA to animals and humans, both by itself or in combination with other mycotoxins. The review also discusses CPA biosynthesis and the genetic diversity of CPA production in A. flavus/oryzae populations. Molecular Diversity Preservation International 2009-11-06 /pmc/articles/PMC3202784/ /pubmed/22069533 http://dx.doi.org/10.3390/toxins1020074 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Chang, Perng-Kuang
Ehrlich, Kenneth C.
Fujii, Isao
Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae
title Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae
title_full Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae
title_fullStr Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae
title_full_unstemmed Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae
title_short Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae
title_sort cyclopiazonic acid biosynthesis of aspergillus flavus and aspergillus oryzae
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202784/
https://www.ncbi.nlm.nih.gov/pubmed/22069533
http://dx.doi.org/10.3390/toxins1020074
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AT fujiiisao cyclopiazonicacidbiosynthesisofaspergillusflavusandaspergillusoryzae

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