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Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202789/ https://www.ncbi.nlm.nih.gov/pubmed/22069537 http://dx.doi.org/10.3390/toxins1020151 |
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author | Komori, Yumiko Nagamizu, Masaya Uchiya, Kei-ichi Nikai, Toshiaki Tu, Anthony T. |
author_facet | Komori, Yumiko Nagamizu, Masaya Uchiya, Kei-ichi Nikai, Toshiaki Tu, Anthony T. |
author_sort | Komori, Yumiko |
collection | PubMed |
description | Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins were determined, and then compared to cobra neurotoxins by computer modeling. This allowed for easy comparison of the similarities and differences between the two types of postsynaptic neurotoxins. Comparison of computer models for the toxins of sea snakes and cobra will reveal the three dimensional difference of the toxins much clearer than the amino acid sequence alone. |
format | Online Article Text |
id | pubmed-3202789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-32027892011-11-08 Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin Komori, Yumiko Nagamizu, Masaya Uchiya, Kei-ichi Nikai, Toshiaki Tu, Anthony T. Toxins (Basel) Article Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins were determined, and then compared to cobra neurotoxins by computer modeling. This allowed for easy comparison of the similarities and differences between the two types of postsynaptic neurotoxins. Comparison of computer models for the toxins of sea snakes and cobra will reveal the three dimensional difference of the toxins much clearer than the amino acid sequence alone. Molecular Diversity Preservation International 2009-12-03 /pmc/articles/PMC3202789/ /pubmed/22069537 http://dx.doi.org/10.3390/toxins1020151 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Komori, Yumiko Nagamizu, Masaya Uchiya, Kei-ichi Nikai, Toshiaki Tu, Anthony T. Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin |
title | Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin |
title_full | Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin |
title_fullStr | Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin |
title_full_unstemmed | Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin |
title_short | Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin |
title_sort | comparison of sea snake (hydrophiidae) neurotoxin to cobra (naja) neurotoxin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202789/ https://www.ncbi.nlm.nih.gov/pubmed/22069537 http://dx.doi.org/10.3390/toxins1020151 |
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