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Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin

Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences o...

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Autores principales: Komori, Yumiko, Nagamizu, Masaya, Uchiya, Kei-ichi, Nikai, Toshiaki, Tu, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202789/
https://www.ncbi.nlm.nih.gov/pubmed/22069537
http://dx.doi.org/10.3390/toxins1020151
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author Komori, Yumiko
Nagamizu, Masaya
Uchiya, Kei-ichi
Nikai, Toshiaki
Tu, Anthony T.
author_facet Komori, Yumiko
Nagamizu, Masaya
Uchiya, Kei-ichi
Nikai, Toshiaki
Tu, Anthony T.
author_sort Komori, Yumiko
collection PubMed
description Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins were determined, and then compared to cobra neurotoxins by computer modeling. This allowed for easy comparison of the similarities and differences between the two types of postsynaptic neurotoxins. Comparison of computer models for the toxins of sea snakes and cobra will reveal the three dimensional difference of the toxins much clearer than the amino acid sequence alone.
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spelling pubmed-32027892011-11-08 Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin Komori, Yumiko Nagamizu, Masaya Uchiya, Kei-ichi Nikai, Toshiaki Tu, Anthony T. Toxins (Basel) Article Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins were determined, and then compared to cobra neurotoxins by computer modeling. This allowed for easy comparison of the similarities and differences between the two types of postsynaptic neurotoxins. Comparison of computer models for the toxins of sea snakes and cobra will reveal the three dimensional difference of the toxins much clearer than the amino acid sequence alone. Molecular Diversity Preservation International 2009-12-03 /pmc/articles/PMC3202789/ /pubmed/22069537 http://dx.doi.org/10.3390/toxins1020151 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Komori, Yumiko
Nagamizu, Masaya
Uchiya, Kei-ichi
Nikai, Toshiaki
Tu, Anthony T.
Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
title Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
title_full Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
title_fullStr Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
title_full_unstemmed Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
title_short Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
title_sort comparison of sea snake (hydrophiidae) neurotoxin to cobra (naja) neurotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202789/
https://www.ncbi.nlm.nih.gov/pubmed/22069537
http://dx.doi.org/10.3390/toxins1020151
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