Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli

Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time-dependent profiles of these rates can be inferred from simultaneous measurements of precursor mRNA (pre-mRNA) and mature mRNA profiles. Transcriptome-wide...

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Detalles Bibliográficos
Autores principales: Zeisel, Amit, Köstler, Wolfgang J, Molotski, Natali, Tsai, Jonathan M, Krauthgamer, Rita, Jacob-Hirsch, Jasmine, Rechavi, Gideon, Soen, Yoav, Jung, Steffen, Yarden, Yosef, Domany, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202801/
https://www.ncbi.nlm.nih.gov/pubmed/21915116
http://dx.doi.org/10.1038/msb.2011.62

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