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Metabolism of Zearalenone in the Course of Beer Fermentation

Zearalenone (ZON) is a mycotoxin with estrogenic activity, produced by members of Fusarium species, and is found worldwide in a number of cereal crops. It is known to have four active metabolites (α-zearalenol (α-ZOL), β-zearalenol (β-ZOL), α-zearalanol (α-ZAL), and β-zearalanol (β-ZAL)). A highly s...

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Autores principales: Mizutani, Kohei, Nagatomi, Yasushi, Mochizuki, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202815/
https://www.ncbi.nlm.nih.gov/pubmed/22069701
http://dx.doi.org/10.3390/toxins3020134
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author Mizutani, Kohei
Nagatomi, Yasushi
Mochizuki, Naoki
author_facet Mizutani, Kohei
Nagatomi, Yasushi
Mochizuki, Naoki
author_sort Mizutani, Kohei
collection PubMed
description Zearalenone (ZON) is a mycotoxin with estrogenic activity, produced by members of Fusarium species, and is found worldwide in a number of cereal crops. It is known to have four active metabolites (α-zearalenol (α-ZOL), β-zearalenol (β-ZOL), α-zearalanol (α-ZAL), and β-zearalanol (β-ZAL)). A highly sensitive analytical method using liquid chromatography/tandem mass spectrometry using electrospray ionization (LC-ESI-MS/MS) has been established and validated in order to analyze ZON and its metabolites in beer and malt samples. The metabolism of ZON in the course of beer fermentation was further characterized using the artificially contaminated wort by this established method. In the fermented sample, 85.9% of ZON was converted to β-ZOL, which has lower estrogenic activity than that of ZON. These findings indicate that the health risk to humans due to ZON in beer is reduced during the fermentation process.
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spelling pubmed-32028152011-11-08 Metabolism of Zearalenone in the Course of Beer Fermentation Mizutani, Kohei Nagatomi, Yasushi Mochizuki, Naoki Toxins (Basel) Article Zearalenone (ZON) is a mycotoxin with estrogenic activity, produced by members of Fusarium species, and is found worldwide in a number of cereal crops. It is known to have four active metabolites (α-zearalenol (α-ZOL), β-zearalenol (β-ZOL), α-zearalanol (α-ZAL), and β-zearalanol (β-ZAL)). A highly sensitive analytical method using liquid chromatography/tandem mass spectrometry using electrospray ionization (LC-ESI-MS/MS) has been established and validated in order to analyze ZON and its metabolites in beer and malt samples. The metabolism of ZON in the course of beer fermentation was further characterized using the artificially contaminated wort by this established method. In the fermented sample, 85.9% of ZON was converted to β-ZOL, which has lower estrogenic activity than that of ZON. These findings indicate that the health risk to humans due to ZON in beer is reduced during the fermentation process. MDPI 2011-02-14 /pmc/articles/PMC3202815/ /pubmed/22069701 http://dx.doi.org/10.3390/toxins3020134 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mizutani, Kohei
Nagatomi, Yasushi
Mochizuki, Naoki
Metabolism of Zearalenone in the Course of Beer Fermentation
title Metabolism of Zearalenone in the Course of Beer Fermentation
title_full Metabolism of Zearalenone in the Course of Beer Fermentation
title_fullStr Metabolism of Zearalenone in the Course of Beer Fermentation
title_full_unstemmed Metabolism of Zearalenone in the Course of Beer Fermentation
title_short Metabolism of Zearalenone in the Course of Beer Fermentation
title_sort metabolism of zearalenone in the course of beer fermentation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202815/
https://www.ncbi.nlm.nih.gov/pubmed/22069701
http://dx.doi.org/10.3390/toxins3020134
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