From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the...

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Detalles Bibliográficos
Autores principales: Nasiripourdori, Adak, Taly, Valérie, Grutter, Thomas, Taly, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202823/
https://www.ncbi.nlm.nih.gov/pubmed/22069709
http://dx.doi.org/10.3390/toxins3030260
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author Nasiripourdori, Adak
Taly, Valérie
Grutter, Thomas
Taly, Antoine
author_facet Nasiripourdori, Adak
Taly, Valérie
Grutter, Thomas
Taly, Antoine
author_sort Nasiripourdori, Adak
collection PubMed
description Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
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spelling pubmed-32028232011-11-08 From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules Nasiripourdori, Adak Taly, Valérie Grutter, Thomas Taly, Antoine Toxins (Basel) Review Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted. MDPI 2011-03-21 /pmc/articles/PMC3202823/ /pubmed/22069709 http://dx.doi.org/10.3390/toxins3030260 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Nasiripourdori, Adak
Taly, Valérie
Grutter, Thomas
Taly, Antoine
From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
title From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
title_full From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
title_fullStr From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
title_full_unstemmed From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
title_short From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
title_sort from toxins targeting ligand gated ion channels to therapeutic molecules
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202823/
https://www.ncbi.nlm.nih.gov/pubmed/22069709
http://dx.doi.org/10.3390/toxins3030260
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