Cargando…
Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202841/ https://www.ncbi.nlm.nih.gov/pubmed/22069735 http://dx.doi.org/10.3390/toxins3060697 |
_version_ | 1782215044449173504 |
---|---|
author | Polito, Letizia Bortolotti, Massimo Pedrazzi, Manuela Bolognesi, Andrea |
author_facet | Polito, Letizia Bortolotti, Massimo Pedrazzi, Manuela Bolognesi, Andrea |
author_sort | Polito, Letizia |
collection | PubMed |
description | Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active A chain (similar to a type 1 RIP) linked to a B chain with lectin properties. RIP-containing conjugates have been used in many experimental strategies against cancer cells, often showing great efficacy in clinical trials. Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L. seeds, has been extensively utilized to construct anti-cancer conjugates because of its high enzymatic activity, stability and resistance to conjugation procedures, resulting in the efficient killing of target cells. This review summarizes saporin-S6-containing conjugates and their application in cancer therapy, considering in-vitro and in-vivo studies both in animal models and in clinical trials. The review is structured on the basis of the targeting of hematological versus solid tumors and on the antigen recognized on the cell surface. |
format | Online Article Text |
id | pubmed-3202841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-32028412011-11-08 Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy Polito, Letizia Bortolotti, Massimo Pedrazzi, Manuela Bolognesi, Andrea Toxins (Basel) Review Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active A chain (similar to a type 1 RIP) linked to a B chain with lectin properties. RIP-containing conjugates have been used in many experimental strategies against cancer cells, often showing great efficacy in clinical trials. Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L. seeds, has been extensively utilized to construct anti-cancer conjugates because of its high enzymatic activity, stability and resistance to conjugation procedures, resulting in the efficient killing of target cells. This review summarizes saporin-S6-containing conjugates and their application in cancer therapy, considering in-vitro and in-vivo studies both in animal models and in clinical trials. The review is structured on the basis of the targeting of hematological versus solid tumors and on the antigen recognized on the cell surface. MDPI 2011-06-22 /pmc/articles/PMC3202841/ /pubmed/22069735 http://dx.doi.org/10.3390/toxins3060697 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Polito, Letizia Bortolotti, Massimo Pedrazzi, Manuela Bolognesi, Andrea Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
title | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
title_full | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
title_fullStr | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
title_full_unstemmed | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
title_short | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
title_sort | immunotoxins and other conjugates containing saporin-s6 for cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202841/ https://www.ncbi.nlm.nih.gov/pubmed/22069735 http://dx.doi.org/10.3390/toxins3060697 |
work_keys_str_mv | AT politoletizia immunotoxinsandotherconjugatescontainingsaporins6forcancertherapy AT bortolottimassimo immunotoxinsandotherconjugatescontainingsaporins6forcancertherapy AT pedrazzimanuela immunotoxinsandotherconjugatescontainingsaporins6forcancertherapy AT bolognesiandrea immunotoxinsandotherconjugatescontainingsaporins6forcancertherapy |