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Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy

Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active...

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Autores principales: Polito, Letizia, Bortolotti, Massimo, Pedrazzi, Manuela, Bolognesi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202841/
https://www.ncbi.nlm.nih.gov/pubmed/22069735
http://dx.doi.org/10.3390/toxins3060697
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author Polito, Letizia
Bortolotti, Massimo
Pedrazzi, Manuela
Bolognesi, Andrea
author_facet Polito, Letizia
Bortolotti, Massimo
Pedrazzi, Manuela
Bolognesi, Andrea
author_sort Polito, Letizia
collection PubMed
description Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active A chain (similar to a type 1 RIP) linked to a B chain with lectin properties. RIP-containing conjugates have been used in many experimental strategies against cancer cells, often showing great efficacy in clinical trials. Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L. seeds, has been extensively utilized to construct anti-cancer conjugates because of its high enzymatic activity, stability and resistance to conjugation procedures, resulting in the efficient killing of target cells. This review summarizes saporin-S6-containing conjugates and their application in cancer therapy, considering in-vitro and in-vivo studies both in animal models and in clinical trials. The review is structured on the basis of the targeting of hematological versus solid tumors and on the antigen recognized on the cell surface.
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spelling pubmed-32028412011-11-08 Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy Polito, Letizia Bortolotti, Massimo Pedrazzi, Manuela Bolognesi, Andrea Toxins (Basel) Review Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active A chain (similar to a type 1 RIP) linked to a B chain with lectin properties. RIP-containing conjugates have been used in many experimental strategies against cancer cells, often showing great efficacy in clinical trials. Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L. seeds, has been extensively utilized to construct anti-cancer conjugates because of its high enzymatic activity, stability and resistance to conjugation procedures, resulting in the efficient killing of target cells. This review summarizes saporin-S6-containing conjugates and their application in cancer therapy, considering in-vitro and in-vivo studies both in animal models and in clinical trials. The review is structured on the basis of the targeting of hematological versus solid tumors and on the antigen recognized on the cell surface. MDPI 2011-06-22 /pmc/articles/PMC3202841/ /pubmed/22069735 http://dx.doi.org/10.3390/toxins3060697 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Polito, Letizia
Bortolotti, Massimo
Pedrazzi, Manuela
Bolognesi, Andrea
Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
title Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
title_full Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
title_fullStr Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
title_full_unstemmed Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
title_short Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
title_sort immunotoxins and other conjugates containing saporin-s6 for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202841/
https://www.ncbi.nlm.nih.gov/pubmed/22069735
http://dx.doi.org/10.3390/toxins3060697
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