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Recurrent DNMT3A Mutations in Patients with Myelodysplastic Syndromes

Alterations in DNA methylation have been implicated in the pathogenesis of myelodysplastic syndromes (MDS), although the underlying mechanism remains largely unknown. Methylation of CpG dinucleotides is mediated by DNA methyltransferases, including DNMT1, DNMT3A, and DNMT3B. DNMT3A mutations have re...

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Detalles Bibliográficos
Autores principales:	Walter, Matthew J., Ding, Li, Shen, Dong, Shao, Jin, Grillot, Marcus, McLellan, Michael, Fulton, Robert, Schmidt, Heather, Kalicki-Veizer, Joelle, O’Laughlin, Michelle, Kandoth, Cyriac, Baty, Jack, Westervelt, Peter, DiPersio, John F., Mardis, Elaine R, Wilson, Richard K., Ley, Timothy J., Graubert, Timothy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202965/ https://www.ncbi.nlm.nih.gov/pubmed/21415852 http://dx.doi.org/10.1038/leu.2011.44

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