Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)

Antipsychotic drugs are widely used in treating schizophrenia, bipolar disorder, and other psychiatric disorders. Many of these drugs, despite their therapeutic advantages, substantially increase body weight. We assessed the association of alleles of 31 genes implicated in body weight regulation wit...

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Autores principales: Tiwari, Hemant K., Patki, Amit, Lieberman, Jeffrey, Stroup, T. Scott, Allison, David B., Leibel, Rudolph L., Chung, Wendy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202977/
https://www.ncbi.nlm.nih.gov/pubmed/22039372
http://dx.doi.org/10.3389/fgene.2011.00056
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author Tiwari, Hemant K.
Patki, Amit
Lieberman, Jeffrey
Stroup, T. Scott
Allison, David B.
Leibel, Rudolph L.
Chung, Wendy K.
author_facet Tiwari, Hemant K.
Patki, Amit
Lieberman, Jeffrey
Stroup, T. Scott
Allison, David B.
Leibel, Rudolph L.
Chung, Wendy K.
author_sort Tiwari, Hemant K.
collection PubMed
description Antipsychotic drugs are widely used in treating schizophrenia, bipolar disorder, and other psychiatric disorders. Many of these drugs, despite their therapeutic advantages, substantially increase body weight. We assessed the association of alleles of 31 genes implicated in body weight regulation with weight gain among patients being treated with specific antipsychotic medications in the clinical antipsychotic trials in intervention effectiveness study, we found that rs2237988 in Potassium Channel Inwardly Rectifying Subfamily J Member 11 (KCNJ11), rs13269119 in Solute carrier family 30 member 8 (SLC30A8), and rs9922047 in fat mass and obesity associated (FTO) were associated with percent weight gain. We also observed the significant interaction of rs11643744 by treatment effect on the weight gain.
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spelling pubmed-32029772011-10-27 Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study) Tiwari, Hemant K. Patki, Amit Lieberman, Jeffrey Stroup, T. Scott Allison, David B. Leibel, Rudolph L. Chung, Wendy K. Front Genet Genetics Antipsychotic drugs are widely used in treating schizophrenia, bipolar disorder, and other psychiatric disorders. Many of these drugs, despite their therapeutic advantages, substantially increase body weight. We assessed the association of alleles of 31 genes implicated in body weight regulation with weight gain among patients being treated with specific antipsychotic medications in the clinical antipsychotic trials in intervention effectiveness study, we found that rs2237988 in Potassium Channel Inwardly Rectifying Subfamily J Member 11 (KCNJ11), rs13269119 in Solute carrier family 30 member 8 (SLC30A8), and rs9922047 in fat mass and obesity associated (FTO) were associated with percent weight gain. We also observed the significant interaction of rs11643744 by treatment effect on the weight gain. Frontiers Research Foundation 2011-09-01 /pmc/articles/PMC3202977/ /pubmed/22039372 http://dx.doi.org/10.3389/fgene.2011.00056 Text en Copyright © 2011 Tiwari, Patki, Lieberman, Stroup, Allison, Leibel and Chung. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Genetics
Tiwari, Hemant K.
Patki, Amit
Lieberman, Jeffrey
Stroup, T. Scott
Allison, David B.
Leibel, Rudolph L.
Chung, Wendy K.
Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)
title Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)
title_full Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)
title_fullStr Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)
title_full_unstemmed Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)
title_short Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)
title_sort association of allelic variation in genes mediating aspects of energy homeostasis with weight gain during administration of antipsychotic drugs (catie study)
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202977/
https://www.ncbi.nlm.nih.gov/pubmed/22039372
http://dx.doi.org/10.3389/fgene.2011.00056
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