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Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study

BACKGROUND: Breast cancer (BC) is the most common cancer for women in the western world. From very few cases an extraordinary increase in BC was observed in the Inuit population of Greenland and Canada although still lower than in western populations. Previous data suggest that exposure to persisten...

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Autores principales: Bonefeld-Jorgensen, Eva C, Long, Manhai, Bossi, Rossana, Ayotte, Pierre, Asmund, Gert, Krüger, Tanja, Ghisari, Mandana, Mulvad, Gert, Kern, Peder, Nzulumiki, Peter, Dewailly, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203030/
https://www.ncbi.nlm.nih.gov/pubmed/21978366
http://dx.doi.org/10.1186/1476-069X-10-88
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author Bonefeld-Jorgensen, Eva C
Long, Manhai
Bossi, Rossana
Ayotte, Pierre
Asmund, Gert
Krüger, Tanja
Ghisari, Mandana
Mulvad, Gert
Kern, Peder
Nzulumiki, Peter
Dewailly, Eric
author_facet Bonefeld-Jorgensen, Eva C
Long, Manhai
Bossi, Rossana
Ayotte, Pierre
Asmund, Gert
Krüger, Tanja
Ghisari, Mandana
Mulvad, Gert
Kern, Peder
Nzulumiki, Peter
Dewailly, Eric
author_sort Bonefeld-Jorgensen, Eva C
collection PubMed
description BACKGROUND: Breast cancer (BC) is the most common cancer for women in the western world. From very few cases an extraordinary increase in BC was observed in the Inuit population of Greenland and Canada although still lower than in western populations. Previous data suggest that exposure to persistent organic pollutants (POPs) might contribute to the risk of BC. Rat studies showed that perfluorinated compounds (PFCs) cause significantly increase in mammary fibroadenomas. This study aimed at evaluating the association between serum levels of POPs/PFCs in Greenlandic Inuit BC cases and their controls, and whether the combined POP related effect on nuclear hormone receptors affect BC risk. METHODS: Thirty-one BC cases and 115 controls were sampled during 2000-2003 from various Greenlandic districts. The serum levels of POPs, PFCs, some metals and the combined serum POP related effect on estrogen- (ER), androgen- (AR) and Ah-receptor (AhR) transactivity were determined. Independent student t-test was used to compare the differences and the odds ratios were estimated by unconditional logistic regression models. RESULTS: We observed for the very first time a significant association between serum PFC levels and the risk of BC. The BC cases also showed a significantly higher concentration of polychlorinated biphenyls at the highest quartile. Also for the combined serum POP induced agonistic AR transactivity significant association to BC risk was found, and cases elicited a higher frequency of samples with significant POP related hormone-like agonistic ER transactivity. The AhR toxic equivalent was lowest in cases. CONCLUSIONS: The level of serum POPs, particularly PFCs, might be risk factors in the development of BC in Inuit. Hormone disruption by the combined serum POP related xenoestrogenic and xenoandrogenic activities may contribute to the risk of developing breast cancer in Inuit. Further investigations are needed to document these study conclusions.
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spelling pubmed-32030302011-10-28 Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study Bonefeld-Jorgensen, Eva C Long, Manhai Bossi, Rossana Ayotte, Pierre Asmund, Gert Krüger, Tanja Ghisari, Mandana Mulvad, Gert Kern, Peder Nzulumiki, Peter Dewailly, Eric Environ Health Research BACKGROUND: Breast cancer (BC) is the most common cancer for women in the western world. From very few cases an extraordinary increase in BC was observed in the Inuit population of Greenland and Canada although still lower than in western populations. Previous data suggest that exposure to persistent organic pollutants (POPs) might contribute to the risk of BC. Rat studies showed that perfluorinated compounds (PFCs) cause significantly increase in mammary fibroadenomas. This study aimed at evaluating the association between serum levels of POPs/PFCs in Greenlandic Inuit BC cases and their controls, and whether the combined POP related effect on nuclear hormone receptors affect BC risk. METHODS: Thirty-one BC cases and 115 controls were sampled during 2000-2003 from various Greenlandic districts. The serum levels of POPs, PFCs, some metals and the combined serum POP related effect on estrogen- (ER), androgen- (AR) and Ah-receptor (AhR) transactivity were determined. Independent student t-test was used to compare the differences and the odds ratios were estimated by unconditional logistic regression models. RESULTS: We observed for the very first time a significant association between serum PFC levels and the risk of BC. The BC cases also showed a significantly higher concentration of polychlorinated biphenyls at the highest quartile. Also for the combined serum POP induced agonistic AR transactivity significant association to BC risk was found, and cases elicited a higher frequency of samples with significant POP related hormone-like agonistic ER transactivity. The AhR toxic equivalent was lowest in cases. CONCLUSIONS: The level of serum POPs, particularly PFCs, might be risk factors in the development of BC in Inuit. Hormone disruption by the combined serum POP related xenoestrogenic and xenoandrogenic activities may contribute to the risk of developing breast cancer in Inuit. Further investigations are needed to document these study conclusions. BioMed Central 2011-10-06 /pmc/articles/PMC3203030/ /pubmed/21978366 http://dx.doi.org/10.1186/1476-069X-10-88 Text en Copyright ©2011 Bonefeld-Jorgensen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Bonefeld-Jorgensen, Eva C
Long, Manhai
Bossi, Rossana
Ayotte, Pierre
Asmund, Gert
Krüger, Tanja
Ghisari, Mandana
Mulvad, Gert
Kern, Peder
Nzulumiki, Peter
Dewailly, Eric
Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study
title Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study
title_full Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study
title_fullStr Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study
title_full_unstemmed Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study
title_short Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study
title_sort perfluorinated compounds are related to breast cancer risk in greenlandic inuit: a case control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203030/
https://www.ncbi.nlm.nih.gov/pubmed/21978366
http://dx.doi.org/10.1186/1476-069X-10-88
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