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Coordinated Destruction of Cellular Messages in Translation Complexes by the Gammaherpesvirus Host Shutoff Factor and the Mammalian Exonuclease Xrn1

Several viruses encode factors that promote host mRNA degradation to silence gene expression. It is unclear, however, whether cellular mRNA turnover pathways are engaged to assist in this process. In Kaposi's sarcoma-associated herpesvirus this phenotype is enacted by the host shutoff factor SO...

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Detalles Bibliográficos
Autores principales:	Covarrubias, Sergio, Gaglia, Marta M., Kumar, G. Renuka, Wong, Wesley, Jackson, Andrew O., Glaunsinger, Britt A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203186/ https://www.ncbi.nlm.nih.gov/pubmed/22046136 http://dx.doi.org/10.1371/journal.ppat.1002339

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