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A reaction-diffusion model of the receptor-toxin-antibody interaction
BACKGROUND: It was recently shown that the treatment effect of an antibody can be described by a consolidated parameter which includes the reaction rates of the receptor-toxin-antibody kinetics and the relative concentration of reacting species. As a result, any given value of this parameter determi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203254/ https://www.ncbi.nlm.nih.gov/pubmed/21896208 http://dx.doi.org/10.1186/1742-4682-8-32 |
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author | Skakauskas, Vladas Katauskis, Pranas Skvortsov, Alex |
author_facet | Skakauskas, Vladas Katauskis, Pranas Skvortsov, Alex |
author_sort | Skakauskas, Vladas |
collection | PubMed |
description | BACKGROUND: It was recently shown that the treatment effect of an antibody can be described by a consolidated parameter which includes the reaction rates of the receptor-toxin-antibody kinetics and the relative concentration of reacting species. As a result, any given value of this parameter determines an associated range of antibody kinetic properties and its relative concentration in order to achieve a desirable therapeutic effect. In the current study we generalize the existing kinetic model by explicitly taking into account the diffusion fluxes of the species. RESULTS: A refined model of receptor-toxin-antibody (RTA) interaction is studied numerically. The protective properties of an antibody against a given toxin are evaluated for a spherical cell placed into a toxin-antibody solution. The selection of parameters for numerical simulation approximately corresponds to the practically relevant values reported in the literature with the significant ranges in variation to allow demonstration of different regimes of intracellular transport. CONCLUSIONS: The proposed refinement of the RTA model may become important for the consistent evaluation of protective potential of an antibody and for the estimation of the time period during which the application of this antibody becomes the most effective. It can be a useful tool for in vitro selection of potential protective antibodies for progression to in vivo evaluation. |
format | Online Article Text |
id | pubmed-3203254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32032542011-10-31 A reaction-diffusion model of the receptor-toxin-antibody interaction Skakauskas, Vladas Katauskis, Pranas Skvortsov, Alex Theor Biol Med Model Research BACKGROUND: It was recently shown that the treatment effect of an antibody can be described by a consolidated parameter which includes the reaction rates of the receptor-toxin-antibody kinetics and the relative concentration of reacting species. As a result, any given value of this parameter determines an associated range of antibody kinetic properties and its relative concentration in order to achieve a desirable therapeutic effect. In the current study we generalize the existing kinetic model by explicitly taking into account the diffusion fluxes of the species. RESULTS: A refined model of receptor-toxin-antibody (RTA) interaction is studied numerically. The protective properties of an antibody against a given toxin are evaluated for a spherical cell placed into a toxin-antibody solution. The selection of parameters for numerical simulation approximately corresponds to the practically relevant values reported in the literature with the significant ranges in variation to allow demonstration of different regimes of intracellular transport. CONCLUSIONS: The proposed refinement of the RTA model may become important for the consistent evaluation of protective potential of an antibody and for the estimation of the time period during which the application of this antibody becomes the most effective. It can be a useful tool for in vitro selection of potential protective antibodies for progression to in vivo evaluation. BioMed Central 2011-09-07 /pmc/articles/PMC3203254/ /pubmed/21896208 http://dx.doi.org/10.1186/1742-4682-8-32 Text en Copyright ©2011 Skakauskas et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Skakauskas, Vladas Katauskis, Pranas Skvortsov, Alex A reaction-diffusion model of the receptor-toxin-antibody interaction |
title | A reaction-diffusion model of the receptor-toxin-antibody interaction |
title_full | A reaction-diffusion model of the receptor-toxin-antibody interaction |
title_fullStr | A reaction-diffusion model of the receptor-toxin-antibody interaction |
title_full_unstemmed | A reaction-diffusion model of the receptor-toxin-antibody interaction |
title_short | A reaction-diffusion model of the receptor-toxin-antibody interaction |
title_sort | reaction-diffusion model of the receptor-toxin-antibody interaction |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203254/ https://www.ncbi.nlm.nih.gov/pubmed/21896208 http://dx.doi.org/10.1186/1742-4682-8-32 |
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