One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria

Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MSRA) and vancomycin-resistant Enterococcus faecium (VRE) with MICs as low as ~...

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Detalles Bibliográficos
Autores principales: Moraski, Garrett C., Thanassi, Jane A., Podos, Steven D., Pucci, Michael J., Miller, Marvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203319/
https://www.ncbi.nlm.nih.gov/pubmed/21811261
http://dx.doi.org/10.1038/ja.2011.67
Descripción
Sumario:Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MSRA) and vancomycin-resistant Enterococcus faecium (VRE) with MICs as low as ~1 µg/ml.

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