Cargando…
One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria
Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MSRA) and vancomycin-resistant Enterococcus faecium (VRE) with MICs as low as ~...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203319/ https://www.ncbi.nlm.nih.gov/pubmed/21811261 http://dx.doi.org/10.1038/ja.2011.67 |
_version_ | 1782215106819522560 |
---|---|
author | Moraski, Garrett C. Thanassi, Jane A. Podos, Steven D. Pucci, Michael J. Miller, Marvin J. |
author_facet | Moraski, Garrett C. Thanassi, Jane A. Podos, Steven D. Pucci, Michael J. Miller, Marvin J. |
author_sort | Moraski, Garrett C. |
collection | PubMed |
description | Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MSRA) and vancomycin-resistant Enterococcus faecium (VRE) with MICs as low as ~1 µg/ml. |
format | Online Article Text |
id | pubmed-3203319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
record_format | MEDLINE/PubMed |
spelling | pubmed-32033192012-04-01 One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria Moraski, Garrett C. Thanassi, Jane A. Podos, Steven D. Pucci, Michael J. Miller, Marvin J. J Antibiot (Tokyo) Article Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MSRA) and vancomycin-resistant Enterococcus faecium (VRE) with MICs as low as ~1 µg/ml. 2011-08-03 2011-10 /pmc/articles/PMC3203319/ /pubmed/21811261 http://dx.doi.org/10.1038/ja.2011.67 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Moraski, Garrett C. Thanassi, Jane A. Podos, Steven D. Pucci, Michael J. Miller, Marvin J. One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria |
title | One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria |
title_full | One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria |
title_fullStr | One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria |
title_full_unstemmed | One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria |
title_short | One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria |
title_sort | one step syntheses of nitrofuranyl benzimidazoles that are active against multi-drug resistant bacteria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203319/ https://www.ncbi.nlm.nih.gov/pubmed/21811261 http://dx.doi.org/10.1038/ja.2011.67 |
work_keys_str_mv | AT moraskigarrettc onestepsynthesesofnitrofuranylbenzimidazolesthatareactiveagainstmultidrugresistantbacteria AT thanassijanea onestepsynthesesofnitrofuranylbenzimidazolesthatareactiveagainstmultidrugresistantbacteria AT podosstevend onestepsynthesesofnitrofuranylbenzimidazolesthatareactiveagainstmultidrugresistantbacteria AT puccimichaelj onestepsynthesesofnitrofuranylbenzimidazolesthatareactiveagainstmultidrugresistantbacteria AT millermarvinj onestepsynthesesofnitrofuranylbenzimidazolesthatareactiveagainstmultidrugresistantbacteria |