One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria

Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MSRA) and vancomycin-resistant Enterococcus faecium (VRE) with MICs as low as ~...

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Detalles Bibliográficos
Autores principales: Moraski, Garrett C., Thanassi, Jane A., Podos, Steven D., Pucci, Michael J., Miller, Marvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203319/
https://www.ncbi.nlm.nih.gov/pubmed/21811261
http://dx.doi.org/10.1038/ja.2011.67
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author Moraski, Garrett C.
Thanassi, Jane A.
Podos, Steven D.
Pucci, Michael J.
Miller, Marvin J.
author_facet Moraski, Garrett C.
Thanassi, Jane A.
Podos, Steven D.
Pucci, Michael J.
Miller, Marvin J.
author_sort Moraski, Garrett C.
collection PubMed
description Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MSRA) and vancomycin-resistant Enterococcus faecium (VRE) with MICs as low as ~1 µg/ml.
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spelling pubmed-32033192012-04-01 One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria Moraski, Garrett C. Thanassi, Jane A. Podos, Steven D. Pucci, Michael J. Miller, Marvin J. J Antibiot (Tokyo) Article Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MSRA) and vancomycin-resistant Enterococcus faecium (VRE) with MICs as low as ~1 µg/ml. 2011-08-03 2011-10 /pmc/articles/PMC3203319/ /pubmed/21811261 http://dx.doi.org/10.1038/ja.2011.67 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Moraski, Garrett C.
Thanassi, Jane A.
Podos, Steven D.
Pucci, Michael J.
Miller, Marvin J.
One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria
title One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria
title_full One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria
title_fullStr One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria
title_full_unstemmed One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria
title_short One Step Syntheses of Nitrofuranyl Benzimidazoles that are Active Against Multi-Drug Resistant Bacteria
title_sort one step syntheses of nitrofuranyl benzimidazoles that are active against multi-drug resistant bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203319/
https://www.ncbi.nlm.nih.gov/pubmed/21811261
http://dx.doi.org/10.1038/ja.2011.67
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