Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche

Depolarization by the neurotransmitter GABA regulates adult neurogenesis. Here we show that interneurons of the neurogliaform cell family are a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurs in concert with reduced synaptic inhibition of mature neu...

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Autores principales: Markwardt, Sean J., Dieni, Cristina V., Wadiche, Jacques I., Overstreet-Wadiche, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203322/
https://www.ncbi.nlm.nih.gov/pubmed/21983681
http://dx.doi.org/10.1038/nn.2935
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author Markwardt, Sean J.
Dieni, Cristina V.
Wadiche, Jacques I.
Overstreet-Wadiche, Linda
author_facet Markwardt, Sean J.
Dieni, Cristina V.
Wadiche, Jacques I.
Overstreet-Wadiche, Linda
author_sort Markwardt, Sean J.
collection PubMed
description Depolarization by the neurotransmitter GABA regulates adult neurogenesis. Here we show that interneurons of the neurogliaform cell family are a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurs in concert with reduced synaptic inhibition of mature neurons, suggesting the local circuitry facilitates coordinated activation of new and pre-existing cells.
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spelling pubmed-32033222012-05-01 Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche Markwardt, Sean J. Dieni, Cristina V. Wadiche, Jacques I. Overstreet-Wadiche, Linda Nat Neurosci Article Depolarization by the neurotransmitter GABA regulates adult neurogenesis. Here we show that interneurons of the neurogliaform cell family are a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurs in concert with reduced synaptic inhibition of mature neurons, suggesting the local circuitry facilitates coordinated activation of new and pre-existing cells. 2011-10-09 /pmc/articles/PMC3203322/ /pubmed/21983681 http://dx.doi.org/10.1038/nn.2935 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Markwardt, Sean J.
Dieni, Cristina V.
Wadiche, Jacques I.
Overstreet-Wadiche, Linda
Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche
title Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche
title_full Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche
title_fullStr Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche
title_full_unstemmed Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche
title_short Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche
title_sort ivy/neurogliaform interneurons coordinate activity in the neurogenic niche
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203322/
https://www.ncbi.nlm.nih.gov/pubmed/21983681
http://dx.doi.org/10.1038/nn.2935
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