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A Novel Nuclear Role for the Vav3 Nucleotide Exchange Factor in Androgen Receptor Coactivation in Prostate Cancer
Increased androgen receptor (AR) transcriptional activity mediated by coactivator proteins may drive castration resistant prostate cancer (CRPC) growth. Vav3, a Rho GTPase guanine nucleotide exchange factor (GEF), is over-expressed in human prostate cancers particularly in models of CRPC progression...
Autores principales: | Rao, Shuyun, Lyons, Leah S., Fahrenholtz, Cale D., Wu, Fayi, Farooq, Amjad, Balkan, Wayne, Burnstein, Kerry L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203328/ https://www.ncbi.nlm.nih.gov/pubmed/21765461 http://dx.doi.org/10.1038/onc.2011.273 |
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