Amygdala lesions selectively impair familiarity in recognition memory

A major controversy in the study of memory concerns whether there are distinct medial temporal lobe (MTL) substrates of recollection and familiarity. Studies using Received Operating Characteristics (ROC) analyses of recognition memory indicate that the hippocampus is essential to recollection but n...

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Detalles Bibliográficos
Autores principales: Farovik, Anja, Place, Ryan, Miller, Danielle, Eichenbaum, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203336/
https://www.ncbi.nlm.nih.gov/pubmed/21946327
http://dx.doi.org/10.1038/nn.2919
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author Farovik, Anja
Place, Ryan
Miller, Danielle
Eichenbaum, Howard
author_facet Farovik, Anja
Place, Ryan
Miller, Danielle
Eichenbaum, Howard
author_sort Farovik, Anja
collection PubMed
description A major controversy in the study of memory concerns whether there are distinct medial temporal lobe (MTL) substrates of recollection and familiarity. Studies using Received Operating Characteristics (ROC) analyses of recognition memory indicate that the hippocampus is essential to recollection but not familiarity. We report the converse pattern wherein amygdala damage impairs familiarity while sparing recollection. Combined with previous findings, these results dissociate recollection and familiarity by selective MTL damage.
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spelling pubmed-32033362012-05-01 Amygdala lesions selectively impair familiarity in recognition memory Farovik, Anja Place, Ryan Miller, Danielle Eichenbaum, Howard Nat Neurosci Article A major controversy in the study of memory concerns whether there are distinct medial temporal lobe (MTL) substrates of recollection and familiarity. Studies using Received Operating Characteristics (ROC) analyses of recognition memory indicate that the hippocampus is essential to recollection but not familiarity. We report the converse pattern wherein amygdala damage impairs familiarity while sparing recollection. Combined with previous findings, these results dissociate recollection and familiarity by selective MTL damage. 2011-09-25 /pmc/articles/PMC3203336/ /pubmed/21946327 http://dx.doi.org/10.1038/nn.2919 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Farovik, Anja
Place, Ryan
Miller, Danielle
Eichenbaum, Howard
Amygdala lesions selectively impair familiarity in recognition memory
title Amygdala lesions selectively impair familiarity in recognition memory
title_full Amygdala lesions selectively impair familiarity in recognition memory
title_fullStr Amygdala lesions selectively impair familiarity in recognition memory
title_full_unstemmed Amygdala lesions selectively impair familiarity in recognition memory
title_short Amygdala lesions selectively impair familiarity in recognition memory
title_sort amygdala lesions selectively impair familiarity in recognition memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203336/
https://www.ncbi.nlm.nih.gov/pubmed/21946327
http://dx.doi.org/10.1038/nn.2919
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