Sleep and wake modulate spine turnover in the adolescent mouse cortex

Cortical development involves synaptic formation and elimination. While synaptogenesis predominates earlier and pruning later, the two processes are thought to happen concurrently. Since in adults synaptic strength is modulated by behavioral state, we asked if synaptic remodeling may be affected by...

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Detalles Bibliográficos
Autores principales: Maret, Stephanie, Faraguna, Ugo, Nelson, Aaron B, Cirelli, Chiara, Tononi, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203346/
https://www.ncbi.nlm.nih.gov/pubmed/21983682
http://dx.doi.org/10.1038/nn.2934
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author Maret, Stephanie
Faraguna, Ugo
Nelson, Aaron B
Cirelli, Chiara
Tononi, Giulio
author_facet Maret, Stephanie
Faraguna, Ugo
Nelson, Aaron B
Cirelli, Chiara
Tononi, Giulio
author_sort Maret, Stephanie
collection PubMed
description Cortical development involves synaptic formation and elimination. While synaptogenesis predominates earlier and pruning later, the two processes are thought to happen concurrently. Since in adults synaptic strength is modulated by behavioral state, we asked if synaptic remodeling may be affected by sleep and wake. Using two-photon microscopy in adolescent mice, we found that wake results in a net increase in cortical spines, whereas sleep is associated with net spine loss.
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spelling pubmed-32033462012-05-01 Sleep and wake modulate spine turnover in the adolescent mouse cortex Maret, Stephanie Faraguna, Ugo Nelson, Aaron B Cirelli, Chiara Tononi, Giulio Nat Neurosci Article Cortical development involves synaptic formation and elimination. While synaptogenesis predominates earlier and pruning later, the two processes are thought to happen concurrently. Since in adults synaptic strength is modulated by behavioral state, we asked if synaptic remodeling may be affected by sleep and wake. Using two-photon microscopy in adolescent mice, we found that wake results in a net increase in cortical spines, whereas sleep is associated with net spine loss. 2011-10-09 /pmc/articles/PMC3203346/ /pubmed/21983682 http://dx.doi.org/10.1038/nn.2934 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Maret, Stephanie
Faraguna, Ugo
Nelson, Aaron B
Cirelli, Chiara
Tononi, Giulio
Sleep and wake modulate spine turnover in the adolescent mouse cortex
title Sleep and wake modulate spine turnover in the adolescent mouse cortex
title_full Sleep and wake modulate spine turnover in the adolescent mouse cortex
title_fullStr Sleep and wake modulate spine turnover in the adolescent mouse cortex
title_full_unstemmed Sleep and wake modulate spine turnover in the adolescent mouse cortex
title_short Sleep and wake modulate spine turnover in the adolescent mouse cortex
title_sort sleep and wake modulate spine turnover in the adolescent mouse cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203346/
https://www.ncbi.nlm.nih.gov/pubmed/21983682
http://dx.doi.org/10.1038/nn.2934
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