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Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection
To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statist...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203390/ https://www.ncbi.nlm.nih.gov/pubmed/21881118 http://dx.doi.org/10.1093/infdis/jir493 |
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author | Loeb, Mark Eskandarian, Sasha Rupp, Mark Fishman, Neil Gasink, Leanne Patterson, Jan Bramson, Jonathan Hudson, Thomas J Lemire, Mathieu |
author_facet | Loeb, Mark Eskandarian, Sasha Rupp, Mark Fishman, Neil Gasink, Leanne Patterson, Jan Bramson, Jonathan Hudson, Thomas J Lemire, Mathieu |
author_sort | Loeb, Mark |
collection | PubMed |
description | To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P = 1.88 × 10(−5); odds ratio [OR], 0.68 [95% confidence interval {CI}, .56–.81]); rs2298771 in SCN1A (sodium channel, neuronal type I α subunit) (P = 5.87 × 10(−5); OR, 1.47 [95% CI, 1.21–1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10(−4); OR, 0.69 [95% CI, .56–.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease. |
format | Online Article Text |
id | pubmed-3203390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32033902012-10-01 Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection Loeb, Mark Eskandarian, Sasha Rupp, Mark Fishman, Neil Gasink, Leanne Patterson, Jan Bramson, Jonathan Hudson, Thomas J Lemire, Mathieu J Infect Dis Major Articles and Brief Reports To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P = 1.88 × 10(−5); odds ratio [OR], 0.68 [95% confidence interval {CI}, .56–.81]); rs2298771 in SCN1A (sodium channel, neuronal type I α subunit) (P = 5.87 × 10(−5); OR, 1.47 [95% CI, 1.21–1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10(−4); OR, 0.69 [95% CI, .56–.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease. Oxford University Press 2011-10-01 2011-10-01 /pmc/articles/PMC3203390/ /pubmed/21881118 http://dx.doi.org/10.1093/infdis/jir493 Text en © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Major Articles and Brief Reports Loeb, Mark Eskandarian, Sasha Rupp, Mark Fishman, Neil Gasink, Leanne Patterson, Jan Bramson, Jonathan Hudson, Thomas J Lemire, Mathieu Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection |
title | Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection |
title_full | Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection |
title_fullStr | Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection |
title_full_unstemmed | Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection |
title_short | Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection |
title_sort | genetic variants and susceptibility to neurological complications following west nile virus infection |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203390/ https://www.ncbi.nlm.nih.gov/pubmed/21881118 http://dx.doi.org/10.1093/infdis/jir493 |
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