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Reprogramming efficiency and quality of induced Pluripotent Stem Cells (iPSCs) generated from muscle-derived fibroblasts of mdx mice at different ages

Induced pluripotent stem cells (iPSCs) hold promise as a potential treatment for Duchenne muscular dystrophy (DMD). To determine the impact of the donor’s age on reprogramming, we generated iPSCs from muscle-derived fibroblasts (MuFs) of mdx mice aged 6 weeks, 6 months, and 14 months. MuFs from 14-m...

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Detalles Bibliográficos
Autores principales:	Wang, Bo, Miyagoe-Suzuki, Yuko, Yada, Erica, Ito, Naoki, Nishiyama, Takashi, Nakamura, Miho, Ono, Yusuke, Motohashi, Norio, Segawa, Makoto, Masuda, Satoru, Takeda, Shin'ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Muscular Dystrophy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203521/ https://www.ncbi.nlm.nih.gov/pubmed/22101343 http://dx.doi.org/10.1371/currents.RRN1274

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