Loss of Zebrafish lgi1b Leads to Hydrocephalus and Sensitization to Pentylenetetrazol Induced Seizure-Like Behavior

Mutations in the LGI1 gene predispose to a hereditary epilepsy syndrome and is the first gene associated with this disease which does not encode an ion channel protein. In zebrafish, there are two paralogs of the LGI1 gene, lgi1a and lgi1b. Knockdown of lgi1a results in a seizure-like hyperactivity...

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Detalles Bibliográficos
Autores principales: Teng, Yong, Xie, Xiayang, Walker, Steven, Saxena, Meera, Kozlowski, David J., Mumm, Jeff S., Cowell, John K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203530/
https://www.ncbi.nlm.nih.gov/pubmed/22053218
http://dx.doi.org/10.1371/journal.pone.0024596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203530/
https://www.ncbi.nlm.nih.gov/pubmed/22053218
http://dx.doi.org/10.1371/journal.pone.0024596

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