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Target site cleavage by the monomeric restriction enzyme BcnI requires translocation to a random DNA sequence and a switch in enzyme orientation

Endonucleases that generate double-strand breaks in DNA often possess two identical subunits related by rotational symmetry, arranged so that the active sites from each subunit act on opposite DNA strands. In contrast to many endonucleases, Type IIP restriction enzyme BcnI, which recognizes the pseu...

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Detalles Bibliográficos
Autores principales:	Sasnauskas, Giedrius, Kostiuk, Georgij, Tamulaitis, Gintautas, Siksnys, Virginijus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203586/ https://www.ncbi.nlm.nih.gov/pubmed/21771860 http://dx.doi.org/10.1093/nar/gkr588

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