Cargando…

Diverse substrate recognition and hydrolysis mechanisms of human NUDT5

Human NUDT5 (hNUDT5) hydrolyzes various modified nucleoside diphosphates including 8-oxo-dGDP, 8-oxo-dADP and ADP-ribose (ADPR). However, the structural basis of the broad substrate specificity remains unknown. Here, we report the crystal structures of hNUDT5 complexed with 8-oxo-dGDP and 8-oxo-dADP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arimori, Takao, Tamaoki, Haruhiko, Nakamura, Teruya, Kamiya, Hiroyuki, Ikemizu, Shinji, Takagi, Yasumitsu, Ishibashi, Toru, Harashima, Hideyoshi, Sekiguchi, Mutsuo, Yamagata, Yuriko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203587/ https://www.ncbi.nlm.nih.gov/pubmed/21768126 http://dx.doi.org/10.1093/nar/gkr575

Ejemplares similares

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
por: Waz, Shaimaa, et al.
Publicado: (2017)

Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer
por: Nakamura, Teruya, et al.
Publicado: (2021)

Mammalian enzymes for preventing transcriptional errors caused by oxidative damage
por: Ishibashi, Toru, et al.
Publicado: (2005)

Crystal structure of endo-1,4-β-glucanase from Eisenia fetida
por: Arimori, Takao, et al.
Publicado: (2013)

PCNA–MutSα-mediated binding of MutLα to replicative DNA with mismatched bases to induce apoptosis in human cells
por: Hidaka, Masumi, et al.
Publicado: (2005)

Substrate specificities of Escherichia coli ItaT that acetylates aminoacyl-tRNAs
por: Zhang, Chuqiao, et al.
Publicado: (2020)

Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates
por: Chrabąszczewska, Magdalena, et al.
Publicado: (2021)

Mechanistic basis for the recognition of laminin-511 by α6β1 integrin
por: Takizawa, Mamoru, et al.
Publicado: (2017)

Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis
por: Jia, Zhihui, et al.
Publicado: (2019)

Structure of the large terminase from a hyperthermophilic virus reveals a unique mechanism for oligomerization and ATP hydrolysis
por: Xu, Rui-Gang, et al.
Publicado: (2017)

Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase
por: Nakamura, Teruya, et al.
Publicado: (2022)

Engineering ACE2 decoy receptors to combat viral escapability
por: Arimori, Takao, et al.
Publicado: (2022)

Structural mechanism of laminin recognition by integrin
por: Arimori, Takao, et al.
Publicado: (2021)

The full-length structure of Thermus scotoductus OLD defines the ATP hydrolysis properties and catalytic mechanism of Class 1 OLD family nucleases
por: Schiltz, Carl J, et al.
Publicado: (2020)

Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90
por: Cunningham, Christian N., et al.
Publicado: (2008)

Role of the NUDT Enzymes in Breast Cancer
por: Wright, Roni H. G., et al.
Publicado: (2021)

Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps
por: Sato, Hideaki, et al.
Publicado: (2021)

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering
por: Yu, Chao, et al.
Publicado: (2011)

Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase
por: Nowacka, Marzena, et al.
Publicado: (2021)

Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells
por: Tsujioka, Takao, et al.
Publicado: (2021)

Crystal structure of RuvC resolvase in complex with Holliday junction substrate
por: Górecka, Karolina M., et al.
Publicado: (2013)

Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase
por: Ito, Kosuke, et al.
Publicado: (2012)

Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation
por: Abula, Abudureyimu, et al.
Publicado: (2021)

Importance of NUDT15 Polymorphisms in Thiopurine Treatments
por: Tanaka, Yoichi, et al.
Publicado: (2021)

Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding
por: Miętus, Michał, et al.
Publicado: (2014)

Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi
por: Li, Wenjing, et al.
Publicado: (2015)

Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA
por: Solomon, William C, et al.
Publicado: (2019)

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates
por: Ditzler, Mark A., et al.
Publicado: (2011)

Structural basis for acceptor RNA substrate selectivity of the 3′ terminal uridylyl transferase Tailor
por: Kroupova, Alena, et al.
Publicado: (2019)

Structural basis for the substrate specificity and catalytic features of pseudouridine kinase from Arabidopsis thaliana
por: Kim, Sang-Hoon, et al.
Publicado: (2020)

Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity
por: Nakamura, Teruya, et al.
Publicado: (2020)

Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB
por: Kimura, Seigo, et al.
Publicado: (2020)

Non-invasive gene delivery across the blood-brain barrier: present and future perspectives
por: Kimura, Seigo, et al.
Publicado: (2021)

Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I
por: Miyazono, Ken-ichi, et al.
Publicado: (2015)

Alternative conformation induced by substrate binding for Arabidopsis thalianaN(6)-methyl-AMP deaminase
por: Jia, Qian, et al.
Publicado: (2019)

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition
por: Ogden, Tom E H, et al.
Publicado: (2021)

Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR–Cas12f nuclease
por: Xiao, Renjian, et al.
Publicado: (2021)

Site-specific epitope insertion into recombinant proteins using the MAP tag system
por: Wakasa, Ayami, et al.
Publicado: (2020)

Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae
por: Moon, Andrea F., et al.
Publicado: (2011)

Structures of an engineered phospholipase D with specificity for secondary alcohol transphosphatidylation: insights into plasticity of substrate binding and activation
por: Samantha, Ariela, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fnmb23k0626d2ki47mvfahodtl