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Local sensing of global DNA topology: from crossover geometry to type II topoisomerase processivity
Type II topoisomerases are ubiquitous enzymes that control the topology and higher order structures of DNA. Type IIA enzymes have the remarkable property to sense locally the global DNA topology. Although many theoretical models have been proposed, the molecular mechanism of chiral discrimination is...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203592/ https://www.ncbi.nlm.nih.gov/pubmed/21764774 http://dx.doi.org/10.1093/nar/gkr556 |