CAG repeats mimic CUG repeats in the misregulation of alternative splicing

Mutant transcripts containing expanded CUG repeats in the untranslated region are a pathogenic factor in myotonic dystrophy type 1 (DM1). The mutant RNA sequesters the muscleblind-like 1 (MBNL1) splicing factor and causes misregulation of the alternative splicing of multiple genes that are linked to...

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Detalles Bibliográficos
Autores principales: Mykowska, Agnieszka, Sobczak, Krzysztof, Wojciechowska, Marzena, Kozlowski, Piotr, Krzyzosiak, Wlodzimierz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203611/
https://www.ncbi.nlm.nih.gov/pubmed/21795378
http://dx.doi.org/10.1093/nar/gkr608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203611/
https://www.ncbi.nlm.nih.gov/pubmed/21795378
http://dx.doi.org/10.1093/nar/gkr608

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