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HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges

T30177 is a G-rich oligonucleotide with the sequence (GTGGTGGGTGGGTGGGT) which inhibits the HIV-1 integrase activity at nanomolar concentrations. Here we show that this DNA sequence forms in K(+) solution a dimeric G-quadruplex structure comprising a total of six G-tetrad layers through the stacking...

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Detalles Bibliográficos
Autores principales:	Mukundan, Vineeth Thachappilly, Do, Ngoc Quang, Phan, Anh Tuân
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203613/ https://www.ncbi.nlm.nih.gov/pubmed/21771859 http://dx.doi.org/10.1093/nar/gkr540

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