A Three-Component Reaction Forming Naphthyridones – Synthesis of Lophocladine Analogs

[Image: see text] A three-component reaction forming dihydro 2,7-naphthyridine-1-ones has been developed. These unstable dihydro intermediates can be either oxidized or reduced to form naphthyridones or tetrahydro naphthyridones, respectively. The reaction tolerates a large variety of aldehydes and...

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Autores principales: Sellstedt, Magnus, Almqvist, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203621/
https://www.ncbi.nlm.nih.gov/pubmed/21879774
http://dx.doi.org/10.1021/ol202080x
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author Sellstedt, Magnus
Almqvist, Fredrik
author_facet Sellstedt, Magnus
Almqvist, Fredrik
author_sort Sellstedt, Magnus
collection PubMed
description [Image: see text] A three-component reaction forming dihydro 2,7-naphthyridine-1-ones has been developed. These unstable dihydro intermediates can be either oxidized or reduced to form naphthyridones or tetrahydro naphthyridones, respectively. The reaction tolerates a large variety of aldehydes and amines, and the produced compounds are analogs of the natural product lophocladine A.
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spelling pubmed-32036212011-10-31 A Three-Component Reaction Forming Naphthyridones – Synthesis of Lophocladine Analogs Sellstedt, Magnus Almqvist, Fredrik Org Lett [Image: see text] A three-component reaction forming dihydro 2,7-naphthyridine-1-ones has been developed. These unstable dihydro intermediates can be either oxidized or reduced to form naphthyridones or tetrahydro naphthyridones, respectively. The reaction tolerates a large variety of aldehydes and amines, and the produced compounds are analogs of the natural product lophocladine A. American Chemical Society 2011-09-01 2011-10-07 /pmc/articles/PMC3203621/ /pubmed/21879774 http://dx.doi.org/10.1021/ol202080x Text en Copyright © 2011 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Sellstedt, Magnus
Almqvist, Fredrik
A Three-Component Reaction Forming Naphthyridones – Synthesis of Lophocladine Analogs
title A Three-Component Reaction Forming Naphthyridones – Synthesis of Lophocladine Analogs
title_full A Three-Component Reaction Forming Naphthyridones – Synthesis of Lophocladine Analogs
title_fullStr A Three-Component Reaction Forming Naphthyridones – Synthesis of Lophocladine Analogs
title_full_unstemmed A Three-Component Reaction Forming Naphthyridones – Synthesis of Lophocladine Analogs
title_short A Three-Component Reaction Forming Naphthyridones – Synthesis of Lophocladine Analogs
title_sort three-component reaction forming naphthyridones – synthesis of lophocladine analogs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203621/
https://www.ncbi.nlm.nih.gov/pubmed/21879774
http://dx.doi.org/10.1021/ol202080x
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