CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications

C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression...

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Autores principales: Liu, Mingli, Guo, Shanchun, Hibbert, Jacqueline M., Jain, Vidhan, Singh, Neeru, Wilson, Nana O., Stiles, Jonathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203691/
https://www.ncbi.nlm.nih.gov/pubmed/21802343
http://dx.doi.org/10.1016/j.cytogfr.2011.06.001
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author Liu, Mingli
Guo, Shanchun
Hibbert, Jacqueline M.
Jain, Vidhan
Singh, Neeru
Wilson, Nana O.
Stiles, Jonathan K.
author_facet Liu, Mingli
Guo, Shanchun
Hibbert, Jacqueline M.
Jain, Vidhan
Singh, Neeru
Wilson, Nana O.
Stiles, Jonathan K.
author_sort Liu, Mingli
collection PubMed
description C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases. A review of the emerging role of CXCL10 in pathogenesis of infectious diseases revealed diverse roles of CXCL10 in disease initiation and progression. The potential utilization of CXCL10 as a therapeutic target for infectious diseases is discussed.
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spelling pubmed-32036912012-07-29 CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications Liu, Mingli Guo, Shanchun Hibbert, Jacqueline M. Jain, Vidhan Singh, Neeru Wilson, Nana O. Stiles, Jonathan K. Cytokine Growth Factor Rev Article C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases. A review of the emerging role of CXCL10 in pathogenesis of infectious diseases revealed diverse roles of CXCL10 in disease initiation and progression. The potential utilization of CXCL10 as a therapeutic target for infectious diseases is discussed. Published by Elsevier Ltd. 2011-06 2011-07-29 /pmc/articles/PMC3203691/ /pubmed/21802343 http://dx.doi.org/10.1016/j.cytogfr.2011.06.001 Text en Copyright © 2011 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Liu, Mingli
Guo, Shanchun
Hibbert, Jacqueline M.
Jain, Vidhan
Singh, Neeru
Wilson, Nana O.
Stiles, Jonathan K.
CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications
title CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications
title_full CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications
title_fullStr CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications
title_full_unstemmed CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications
title_short CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications
title_sort cxcl10/ip-10 in infectious diseases pathogenesis and potential therapeutic implications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203691/
https://www.ncbi.nlm.nih.gov/pubmed/21802343
http://dx.doi.org/10.1016/j.cytogfr.2011.06.001
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