Dengue Type 4 Live-Attenuated Vaccine Viruses Passaged in Vero Cells Affect Genetic Stability and Dengue-Induced Hemorrhaging in Mice

Most live-attenuated tetravalent dengue virus vaccines in current clinical trials are produced from Vero cells. In a previous study we demonstrated that an infectious cDNA clone-derived dengue type 4 (DEN-4) virus retains higher genetic stability in MRC-5 cells than in Vero cells. For this study we...

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Detalles Bibliográficos
Autores principales: Lee, Hsiang-Chi, Yen, Yu-Ting, Chen, Wen-Yu, Wu-Hsieh, Betty A., Wu, Suh-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203870/
https://www.ncbi.nlm.nih.gov/pubmed/22053180
http://dx.doi.org/10.1371/journal.pone.0025800

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