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Phosphoinositide 3-Kinaseγ Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages

Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG) stimulate innate immune responses. Phosphoinositide 3-kinase (PI3K) has been implicated in CpG-induced immune activation; however, its precise role has not yet been clarified. CpG-induced production of IL-10 was dramatically in...

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Detalles Bibliográficos
Autores principales:	Hazeki, Kaoru, Kametani, Yukiko, Murakami, Hiroki, Uehara, Masami, Ishikawa, Yuki, Nigorikawa, Kiyomi, Takasuga, Shunsuke, Sasaki, Takehiko, Seya, Tsukasa, Matsumoto, Misako, Hazeki, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203906/ https://www.ncbi.nlm.nih.gov/pubmed/22053215 http://dx.doi.org/10.1371/journal.pone.0026836

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