Genetic Ablation of PLA2G6 in Mice Leads to Cerebellar Atrophy Characterized by Purkinje Cell Loss and Glial Cell Activation

Infantile neuroaxonal dystrophy (INAD) is a progressive, autosomal recessive neurodegenerative disease characterized by axonal dystrophy, abnormal iron deposition and cerebellar atrophy. This disease was recently mapped to PLA2G6, which encodes group VI Ca(2+)-independent phospholipase A(2) (iPLA(2)...

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Detalles Bibliográficos
Autores principales: Zhao, Zhengshan, Wang, Jing, Zhao, Chunying, Bi, Weina, Yue, Zhenyu, Ma, Zhongmin Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203935/
https://www.ncbi.nlm.nih.gov/pubmed/22046428
http://dx.doi.org/10.1371/journal.pone.0026991

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