Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1

Trimming of mannose residues from the N-linked oligosaccharide precursor is a stringent requirement for glycoprotein endoplasmic reticulum (ER)-associated degradation (ERAD). In this paper, we show that, surprisingly, overexpression of ER degradation–enhancing α-mannosidase-like protein 1 (EDEM1) or...

Descripción completa

Detalles Bibliográficos
Autores principales: Ron, Efrat, Shenkman, Marina, Groisman, Bella, Izenshtein, Yana, Leitman, Julia, Lederkremer, Gerardo Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204057/
https://www.ncbi.nlm.nih.gov/pubmed/21917589
http://dx.doi.org/10.1091/mbc.E10-12-0944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204057/
https://www.ncbi.nlm.nih.gov/pubmed/21917589
http://dx.doi.org/10.1091/mbc.E10-12-0944

Ejemplares similares