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Coupling of T161 and T14 phosphorylations protects cyclin B–CDK1 from premature activation

Mitosis is triggered by the abrupt dephosphorylation of inhibitory Y15 and T14 residues of cyclin B1–bound cyclin-dependent kinase (CDK)1 that is also phosphorylated at T161 in its activation loop. The sequence of events leading to the accumulation of fully phosphorylated cyclin B1–CDK1 complexes re...

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Detalles Bibliográficos
Autores principales:	Coulonval, Katia, Kooken, Hugues, Roger, Pierre P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204060/ https://www.ncbi.nlm.nih.gov/pubmed/21900495 http://dx.doi.org/10.1091/mbc.E11-02-0136

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