Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion

The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is ti...

Descripción completa

Detalles Bibliográficos
Autores principales: Shirley, Sarah, Morizot, Alexandre, Micheau, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204462/
https://www.ncbi.nlm.nih.gov/pubmed/21756247
http://dx.doi.org/10.2174/157489211796957757
_version_ 1782215217078337536
author Shirley, Sarah
Morizot, Alexandre
Micheau, Olivier
author_facet Shirley, Sarah
Morizot, Alexandre
Micheau, Olivier
author_sort Shirley, Sarah
collection PubMed
description The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement.
format Online
Article
Text
id pubmed-3204462
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Bentham Science Publishers
record_format MEDLINE/PubMed
spelling pubmed-32044622011-11-01 Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion Shirley, Sarah Morizot, Alexandre Micheau, Olivier Recent Pat Anticancer Drug Discov Article The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement. Bentham Science Publishers 2011-09 /pmc/articles/PMC3204462/ /pubmed/21756247 http://dx.doi.org/10.2174/157489211796957757 Text en © 2011 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Shirley, Sarah
Morizot, Alexandre
Micheau, Olivier
Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
title Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
title_full Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
title_fullStr Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
title_full_unstemmed Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
title_short Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
title_sort regulating trail receptor-induced cell death at the membrane: a deadly discussion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204462/
https://www.ncbi.nlm.nih.gov/pubmed/21756247
http://dx.doi.org/10.2174/157489211796957757
work_keys_str_mv AT shirleysarah regulatingtrailreceptorinducedcelldeathatthemembraneadeadlydiscussion
AT morizotalexandre regulatingtrailreceptorinducedcelldeathatthemembraneadeadlydiscussion
AT micheauolivier regulatingtrailreceptorinducedcelldeathatthemembraneadeadlydiscussion

Ejemplares similares