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Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients

PURPOSE: Infection with Helicobacter pylori is an important risk factor for gastric cancer in humans. We compared the clinicopathologic features of gastric cancer patients based on H. pylori infection. MATERIALS AND METHODS: We prospectively studied 155 patients who had gastric cancer and underwent...

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Autores principales: Park, Dong-Wook, Lee, Kyu-Jae, Jin, Sung-Ho, Lee, Jae-Hwan, Min, Jae-Seok, Park, Sun-Hoo, Yu, Hang-Jong, Bang, Ho-Yoon, Lee, Jong-Inn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Gastric Cancer Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204496/
https://www.ncbi.nlm.nih.gov/pubmed/22076182
http://dx.doi.org/10.5230/jgc.2010.10.4.168
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author Park, Dong-Wook
Lee, Kyu-Jae
Jin, Sung-Ho
Lee, Jae-Hwan
Min, Jae-Seok
Park, Sun-Hoo
Yu, Hang-Jong
Bang, Ho-Yoon
Lee, Jong-Inn
author_facet Park, Dong-Wook
Lee, Kyu-Jae
Jin, Sung-Ho
Lee, Jae-Hwan
Min, Jae-Seok
Park, Sun-Hoo
Yu, Hang-Jong
Bang, Ho-Yoon
Lee, Jong-Inn
author_sort Park, Dong-Wook
collection PubMed
description PURPOSE: Infection with Helicobacter pylori is an important risk factor for gastric cancer in humans. We compared the clinicopathologic features of gastric cancer patients based on H. pylori infection. MATERIALS AND METHODS: We prospectively studied 155 patients who had gastric cancer and underwent gastrectomies in 1 hospital in Korea. We examined H. pylori infections using the rapid urease test (RUT) with gastrectomy specimens and collected clinical and pathologic data. RESULTS: The number of H. pylori infections based on the RUT was 137 (88%). The H. pylori-negative group was significantly associated with AGC and tumor histology. H. pylori infection was significantly correlated with type I/IIa in EGC and type III/IV/V in AGC. AGC was significantly correlated with larger tumor size, lymphatic invasion, perineural invasion, and H. pylori infection based on univariate and multivariate analyses. CONCLUSIONS: We report the prevalence of H. pylori based on the RUT in gastric cancer patients. H. pylori infection influences the tumor histology, progression, and growth type of gastric cancer.
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spelling pubmed-32044962011-11-10 Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients Park, Dong-Wook Lee, Kyu-Jae Jin, Sung-Ho Lee, Jae-Hwan Min, Jae-Seok Park, Sun-Hoo Yu, Hang-Jong Bang, Ho-Yoon Lee, Jong-Inn J Gastric Cancer Original Article PURPOSE: Infection with Helicobacter pylori is an important risk factor for gastric cancer in humans. We compared the clinicopathologic features of gastric cancer patients based on H. pylori infection. MATERIALS AND METHODS: We prospectively studied 155 patients who had gastric cancer and underwent gastrectomies in 1 hospital in Korea. We examined H. pylori infections using the rapid urease test (RUT) with gastrectomy specimens and collected clinical and pathologic data. RESULTS: The number of H. pylori infections based on the RUT was 137 (88%). The H. pylori-negative group was significantly associated with AGC and tumor histology. H. pylori infection was significantly correlated with type I/IIa in EGC and type III/IV/V in AGC. AGC was significantly correlated with larger tumor size, lymphatic invasion, perineural invasion, and H. pylori infection based on univariate and multivariate analyses. CONCLUSIONS: We report the prevalence of H. pylori based on the RUT in gastric cancer patients. H. pylori infection influences the tumor histology, progression, and growth type of gastric cancer. The Korean Gastric Cancer Association 2010-12 2010-12-31 /pmc/articles/PMC3204496/ /pubmed/22076182 http://dx.doi.org/10.5230/jgc.2010.10.4.168 Text en Copyright © 2010 by The Korean Gastric Cancer Association http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Dong-Wook
Lee, Kyu-Jae
Jin, Sung-Ho
Lee, Jae-Hwan
Min, Jae-Seok
Park, Sun-Hoo
Yu, Hang-Jong
Bang, Ho-Yoon
Lee, Jong-Inn
Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients
title Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients
title_full Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients
title_fullStr Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients
title_full_unstemmed Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients
title_short Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients
title_sort phenotypic differences of gastric cancer according to the helicobacter pylori infection in korean patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204496/
https://www.ncbi.nlm.nih.gov/pubmed/22076182
http://dx.doi.org/10.5230/jgc.2010.10.4.168
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