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Clinicopathological Features of Upper Third Gastric Cancer during a 21-Year Period (Single Center Analysis)

PURPOSE: The aim of this study was to determine proportions of upper third gastric cancer (UTG) among all gastric cancers and analyze clinicopathological features of the disease. MATERIALS AND METHODS: The medical records of 12,300 patients who underwent gastric surgery between 1986 and 2006 at Seou...

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Autores principales: Jang, Je-Ho, Beron, Reinaldo Isaacs, Ahn, Hye Seong, Kong, Seong-Ho, Lee, Hyuk-Joon, Kim, Woo-Ho, Lee, Kuhn Uk, Yang, Han-Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Gastric Cancer Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204506/
https://www.ncbi.nlm.nih.gov/pubmed/22076188
http://dx.doi.org/10.5230/jgc.2010.10.4.212
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author Jang, Je-Ho
Beron, Reinaldo Isaacs
Ahn, Hye Seong
Kong, Seong-Ho
Lee, Hyuk-Joon
Kim, Woo-Ho
Lee, Kuhn Uk
Yang, Han-Kwang
author_facet Jang, Je-Ho
Beron, Reinaldo Isaacs
Ahn, Hye Seong
Kong, Seong-Ho
Lee, Hyuk-Joon
Kim, Woo-Ho
Lee, Kuhn Uk
Yang, Han-Kwang
author_sort Jang, Je-Ho
collection PubMed
description PURPOSE: The aim of this study was to determine proportions of upper third gastric cancer (UTG) among all gastric cancers and analyze clinicopathological features of the disease. MATERIALS AND METHODS: The medical records of 12,300 patients who underwent gastric surgery between 1986 and 2006 at Seoul National University Hospital (SNUH) were retrospectively reviewed. Clinicopathological features of 1,260 patients with UTG and 9,929 patients with middle or lower third gastric cancer (MLG) were compared, and annual proportions of UTG were evaluated. RESULTS: The proportion of patients with UTG rapidly increased from 2.6% in 1986 to 12.5% in 1992. However, linear regression analysis showed that the rate of increase was reduced (0.21%/year) after 1992 (12.5% to 14.2% from 1992 to 2006). Compared with the MLG group, the UTG group had a lower proportion of (22.3% vs. 39.7%, P<0.001) and a greater proportion of stage III/IV disease (39.4% vs. 31.7%, P<0.001). The UTG group also had larger tumors than the MLG group in stages I/II and III (3.5 cm/5.3 cm/6.5 cm vs. 3.2 cm/5.0 cm/5.8 cm, P=0.020/0.028 /<0.001), a higher proportion of undifferentiated cancer (63.1% vs. 53.7%, P<0.001), and less intestinal Lauren's type (38.8% vs. 47.4%, P<0.001). The 5-year survival rate of the UTG group was significantly lower than that of the MLG group in stages I/II and III (85.6%/63.1%/34.2% vs. 91.6%/ 69.2%/44.7%, P<0.001/0.028/0.006). CONCLUSIONS: The proportion of UTGs has increased over the last two decades at SNUH, but the rate of increase has been greatly reduced since 1992. The UTG group showed a poorer prognosis compared with the MLG group in stages I/II and III.
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spelling pubmed-32045062011-11-10 Clinicopathological Features of Upper Third Gastric Cancer during a 21-Year Period (Single Center Analysis) Jang, Je-Ho Beron, Reinaldo Isaacs Ahn, Hye Seong Kong, Seong-Ho Lee, Hyuk-Joon Kim, Woo-Ho Lee, Kuhn Uk Yang, Han-Kwang J Gastric Cancer Original Article PURPOSE: The aim of this study was to determine proportions of upper third gastric cancer (UTG) among all gastric cancers and analyze clinicopathological features of the disease. MATERIALS AND METHODS: The medical records of 12,300 patients who underwent gastric surgery between 1986 and 2006 at Seoul National University Hospital (SNUH) were retrospectively reviewed. Clinicopathological features of 1,260 patients with UTG and 9,929 patients with middle or lower third gastric cancer (MLG) were compared, and annual proportions of UTG were evaluated. RESULTS: The proportion of patients with UTG rapidly increased from 2.6% in 1986 to 12.5% in 1992. However, linear regression analysis showed that the rate of increase was reduced (0.21%/year) after 1992 (12.5% to 14.2% from 1992 to 2006). Compared with the MLG group, the UTG group had a lower proportion of (22.3% vs. 39.7%, P<0.001) and a greater proportion of stage III/IV disease (39.4% vs. 31.7%, P<0.001). The UTG group also had larger tumors than the MLG group in stages I/II and III (3.5 cm/5.3 cm/6.5 cm vs. 3.2 cm/5.0 cm/5.8 cm, P=0.020/0.028 /<0.001), a higher proportion of undifferentiated cancer (63.1% vs. 53.7%, P<0.001), and less intestinal Lauren's type (38.8% vs. 47.4%, P<0.001). The 5-year survival rate of the UTG group was significantly lower than that of the MLG group in stages I/II and III (85.6%/63.1%/34.2% vs. 91.6%/ 69.2%/44.7%, P<0.001/0.028/0.006). CONCLUSIONS: The proportion of UTGs has increased over the last two decades at SNUH, but the rate of increase has been greatly reduced since 1992. The UTG group showed a poorer prognosis compared with the MLG group in stages I/II and III. The Korean Gastric Cancer Association 2010-12 2010-12-31 /pmc/articles/PMC3204506/ /pubmed/22076188 http://dx.doi.org/10.5230/jgc.2010.10.4.212 Text en Copyright © 2010 by The Korean Gastric Cancer Association http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jang, Je-Ho
Beron, Reinaldo Isaacs
Ahn, Hye Seong
Kong, Seong-Ho
Lee, Hyuk-Joon
Kim, Woo-Ho
Lee, Kuhn Uk
Yang, Han-Kwang
Clinicopathological Features of Upper Third Gastric Cancer during a 21-Year Period (Single Center Analysis)
title Clinicopathological Features of Upper Third Gastric Cancer during a 21-Year Period (Single Center Analysis)
title_full Clinicopathological Features of Upper Third Gastric Cancer during a 21-Year Period (Single Center Analysis)
title_fullStr Clinicopathological Features of Upper Third Gastric Cancer during a 21-Year Period (Single Center Analysis)
title_full_unstemmed Clinicopathological Features of Upper Third Gastric Cancer during a 21-Year Period (Single Center Analysis)
title_short Clinicopathological Features of Upper Third Gastric Cancer during a 21-Year Period (Single Center Analysis)
title_sort clinicopathological features of upper third gastric cancer during a 21-year period (single center analysis)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204506/
https://www.ncbi.nlm.nih.gov/pubmed/22076188
http://dx.doi.org/10.5230/jgc.2010.10.4.212
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