Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007

To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994–1997 during a period of high incidence of autochthonous DENV-2 an...

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Autores principales: McElroy, Kate L., Santiago, Gilberto A., Lennon, Niall J., Birren, Bruce W., Henn, Matthew R., Muñoz-Jordán, Jorge L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204641/
https://www.ncbi.nlm.nih.gov/pubmed/21192856
http://dx.doi.org/10.3201/eid1701.100961
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author McElroy, Kate L.
Santiago, Gilberto A.
Lennon, Niall J.
Birren, Bruce W.
Henn, Matthew R.
Muñoz-Jordán, Jorge L.
author_facet McElroy, Kate L.
Santiago, Gilberto A.
Lennon, Niall J.
Birren, Bruce W.
Henn, Matthew R.
Muñoz-Jordán, Jorge L.
author_sort McElroy, Kate L.
collection PubMed
description To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994–1997 during a period of high incidence of autochthonous DENV-2 and frequent, short-lived reintroductions of foreign DENV-2. This unique clade replacement was complete just before DENV-3 emerged. By temporally and geographically defining DENV-2 lineages, we describe a refuge of this virus through 4 years of low genome diversity. Our analyses may explain the long-term endurance of DENV-2 despite great epidemiologic changes in disease incidence and serotype distribution.
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spelling pubmed-32046412011-11-03 Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007 McElroy, Kate L. Santiago, Gilberto A. Lennon, Niall J. Birren, Bruce W. Henn, Matthew R. Muñoz-Jordán, Jorge L. Emerg Infect Dis Research To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994–1997 during a period of high incidence of autochthonous DENV-2 and frequent, short-lived reintroductions of foreign DENV-2. This unique clade replacement was complete just before DENV-3 emerged. By temporally and geographically defining DENV-2 lineages, we describe a refuge of this virus through 4 years of low genome diversity. Our analyses may explain the long-term endurance of DENV-2 despite great epidemiologic changes in disease incidence and serotype distribution. Centers for Disease Control and Prevention 2011-01 /pmc/articles/PMC3204641/ /pubmed/21192856 http://dx.doi.org/10.3201/eid1701.100961 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
McElroy, Kate L.
Santiago, Gilberto A.
Lennon, Niall J.
Birren, Bruce W.
Henn, Matthew R.
Muñoz-Jordán, Jorge L.
Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007
title Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007
title_full Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007
title_fullStr Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007
title_full_unstemmed Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007
title_short Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007
title_sort endurance, refuge, and reemergence of dengue virus type 2, puerto rico, 1986–2007
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204641/
https://www.ncbi.nlm.nih.gov/pubmed/21192856
http://dx.doi.org/10.3201/eid1701.100961
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