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Novel Candidate Genes Associated with Hippocampal Oscillations

The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD r...

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Autores principales: Jansen, Rick, Timmerman, Jaap, Loos, Maarten, Spijker, Sabine, van Ooyen, Arjen, Brussaard, Arjen B., Mansvelder, Huibert D., Smit, August B., de Gunst, Mathisca, Linkenkaer-Hansen, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204991/
https://www.ncbi.nlm.nih.gov/pubmed/22066001
http://dx.doi.org/10.1371/journal.pone.0026586
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author Jansen, Rick
Timmerman, Jaap
Loos, Maarten
Spijker, Sabine
van Ooyen, Arjen
Brussaard, Arjen B.
Mansvelder, Huibert D.
Smit, August B.
de Gunst, Mathisca
Linkenkaer-Hansen, Klaus
author_facet Jansen, Rick
Timmerman, Jaap
Loos, Maarten
Spijker, Sabine
van Ooyen, Arjen
Brussaard, Arjen B.
Mansvelder, Huibert D.
Smit, August B.
de Gunst, Mathisca
Linkenkaer-Hansen, Klaus
author_sort Jansen, Rick
collection PubMed
description The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD recombinant inbred mouse strains. Spontaneous activity and carbachol-induced fast network oscillations were analyzed with spectral and cross-correlation methods and the resulting traits were used for mapping quantitative trait loci (QTLs), i.e., regions on the genome that may influence hippocampal function. Using genome-wide hippocampal gene expression data, we narrowed the QTLs to eight candidate genes, including Plcb1, a phospholipase that is known to influence hippocampal oscillations. We also identified two genes coding for calcium channels, Cacna1b and Cacna1e, which mediate presynaptic transmitter release and have not been shown to regulate hippocampal network activity previously. Furthermore, we showed that the amplitude of the hippocampal oscillations is genetically correlated with hippocampal volume and several measures of novel environment exploration.
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spelling pubmed-32049912011-11-07 Novel Candidate Genes Associated with Hippocampal Oscillations Jansen, Rick Timmerman, Jaap Loos, Maarten Spijker, Sabine van Ooyen, Arjen Brussaard, Arjen B. Mansvelder, Huibert D. Smit, August B. de Gunst, Mathisca Linkenkaer-Hansen, Klaus PLoS One Research Article The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD recombinant inbred mouse strains. Spontaneous activity and carbachol-induced fast network oscillations were analyzed with spectral and cross-correlation methods and the resulting traits were used for mapping quantitative trait loci (QTLs), i.e., regions on the genome that may influence hippocampal function. Using genome-wide hippocampal gene expression data, we narrowed the QTLs to eight candidate genes, including Plcb1, a phospholipase that is known to influence hippocampal oscillations. We also identified two genes coding for calcium channels, Cacna1b and Cacna1e, which mediate presynaptic transmitter release and have not been shown to regulate hippocampal network activity previously. Furthermore, we showed that the amplitude of the hippocampal oscillations is genetically correlated with hippocampal volume and several measures of novel environment exploration. Public Library of Science 2011-10-31 /pmc/articles/PMC3204991/ /pubmed/22066001 http://dx.doi.org/10.1371/journal.pone.0026586 Text en Jansen et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jansen, Rick
Timmerman, Jaap
Loos, Maarten
Spijker, Sabine
van Ooyen, Arjen
Brussaard, Arjen B.
Mansvelder, Huibert D.
Smit, August B.
de Gunst, Mathisca
Linkenkaer-Hansen, Klaus
Novel Candidate Genes Associated with Hippocampal Oscillations
title Novel Candidate Genes Associated with Hippocampal Oscillations
title_full Novel Candidate Genes Associated with Hippocampal Oscillations
title_fullStr Novel Candidate Genes Associated with Hippocampal Oscillations
title_full_unstemmed Novel Candidate Genes Associated with Hippocampal Oscillations
title_short Novel Candidate Genes Associated with Hippocampal Oscillations
title_sort novel candidate genes associated with hippocampal oscillations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204991/
https://www.ncbi.nlm.nih.gov/pubmed/22066001
http://dx.doi.org/10.1371/journal.pone.0026586
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