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Development and optimization of oil-filled lipid nanoparticles containing docetaxel conjugates designed to control the drug release rate in vitro and in vivo

Three docetaxel (DX) lipid conjugates: 2′-lauroyl-docetaxel (C12-DX), 2′-stearoyl-docetaxel (C18-DX), and 2′-behenoyl-docetaxel (C22-DX) were synthesized to enhance drug loading, entrapment, and retention in liquid oil-filled lipid nanoparticles (NPs). The three conjugates showed ten-fold higher sol...

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Detalles Bibliográficos
Autores principales:	Feng, Lan, Wu, Huali, Ma, Ping, Mumper, Russell J, Benhabbour, S Rahima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2011
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205148/ https://www.ncbi.nlm.nih.gov/pubmed/22072889 http://dx.doi.org/10.2147/IJN.S24954

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