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XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole

Background: Asbestos induces DNA and chromosomal damage, but the DNA repair pathways protecting human cells against its genotoxicity are largely unknown. Polymorphisms in XRCC1 have been associated with altered susceptibility to asbestos-related diseases. However, it is unclear whether oxidative DNA...

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Detalles Bibliográficos
Autores principales:	Pietruska, Jodie R., Johnston, Tatiana, Zhitkovich, Anatoly, Kane, Agnes B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205592/ https://www.ncbi.nlm.nih.gov/pubmed/20705543 http://dx.doi.org/10.1289/ehp.1002312

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