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Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis

Randomized trials have confirmed the efficacy and safety of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria. Data from seven studies supported by Novartis (1996–2007), including 647 adults (> 16 years of age, 83.3% completed the study) and 1,332 children...

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Autores principales: Makanga, Michael, Bassat, Quique, Falade, Catherine O., Premji, Zulfiqarali G., Krudsood, Srivicha, Hunt, Philip, Walter, Verena, Beck, Hans-Peter, Marrast, Anne-Claire, Cousin, Marc, Rosenthal, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205621/
https://www.ncbi.nlm.nih.gov/pubmed/22049029
http://dx.doi.org/10.4269/ajtmh.2011.11-0069
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author Makanga, Michael
Bassat, Quique
Falade, Catherine O.
Premji, Zulfiqarali G.
Krudsood, Srivicha
Hunt, Philip
Walter, Verena
Beck, Hans-Peter
Marrast, Anne-Claire
Cousin, Marc
Rosenthal, Philip J.
author_facet Makanga, Michael
Bassat, Quique
Falade, Catherine O.
Premji, Zulfiqarali G.
Krudsood, Srivicha
Hunt, Philip
Walter, Verena
Beck, Hans-Peter
Marrast, Anne-Claire
Cousin, Marc
Rosenthal, Philip J.
author_sort Makanga, Michael
collection PubMed
description Randomized trials have confirmed the efficacy and safety of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria. Data from seven studies supported by Novartis (1996–2007), including 647 adults (> 16 years of age, 83.3% completed the study) and 1,332 children (≤ 16 years of age, 89.3% completed the study) with microscopically confirmed uncomplicated P. falciparum malaria and treated with the recommended regimen of AL, were pooled. The 28-day polymerase chain reaction–corrected parasitologic cure rate (primary efficacy endpoint) was 97.1% (495 of 510) in adults and 97.3% (792 of 814) in children (evaluable population). Gametocytemia prevalence after day was 4.2% (23 of 554) in adults and 0.9% (8 of 846) in children. No noteworthy safety signals were observed. Serious adverse events occurred in 1.4% of the adults and 1.3% of the children. This study is the largest data set to date assessing AL therapy for treatment of acute uncomplicated P. falciparum malaria. Artemether-lumefantrine showed high cure rates and rapid resolution of parasitemia, fever, and gametocytemia in adults and children, and showed an excellent safety and tolerability profile.
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spelling pubmed-32056212011-11-03 Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis Makanga, Michael Bassat, Quique Falade, Catherine O. Premji, Zulfiqarali G. Krudsood, Srivicha Hunt, Philip Walter, Verena Beck, Hans-Peter Marrast, Anne-Claire Cousin, Marc Rosenthal, Philip J. Am J Trop Med Hyg Articles Randomized trials have confirmed the efficacy and safety of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria. Data from seven studies supported by Novartis (1996–2007), including 647 adults (> 16 years of age, 83.3% completed the study) and 1,332 children (≤ 16 years of age, 89.3% completed the study) with microscopically confirmed uncomplicated P. falciparum malaria and treated with the recommended regimen of AL, were pooled. The 28-day polymerase chain reaction–corrected parasitologic cure rate (primary efficacy endpoint) was 97.1% (495 of 510) in adults and 97.3% (792 of 814) in children (evaluable population). Gametocytemia prevalence after day was 4.2% (23 of 554) in adults and 0.9% (8 of 846) in children. No noteworthy safety signals were observed. Serious adverse events occurred in 1.4% of the adults and 1.3% of the children. This study is the largest data set to date assessing AL therapy for treatment of acute uncomplicated P. falciparum malaria. Artemether-lumefantrine showed high cure rates and rapid resolution of parasitemia, fever, and gametocytemia in adults and children, and showed an excellent safety and tolerability profile. The American Society of Tropical Medicine and Hygiene 2011-11-01 /pmc/articles/PMC3205621/ /pubmed/22049029 http://dx.doi.org/10.4269/ajtmh.2011.11-0069 Text en ©The American Society of Tropical Medicine and Hygiene http://creativecommons.org/licenses/by/2.5/ This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Makanga, Michael
Bassat, Quique
Falade, Catherine O.
Premji, Zulfiqarali G.
Krudsood, Srivicha
Hunt, Philip
Walter, Verena
Beck, Hans-Peter
Marrast, Anne-Claire
Cousin, Marc
Rosenthal, Philip J.
Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis
title Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis
title_full Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis
title_fullStr Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis
title_full_unstemmed Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis
title_short Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis
title_sort efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated plasmodium falciparum malaria: a pooled analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205621/
https://www.ncbi.nlm.nih.gov/pubmed/22049029
http://dx.doi.org/10.4269/ajtmh.2011.11-0069
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