Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications

Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of th...

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Detalles Bibliográficos
Autores principales: Win, Myat Thu Thu, Yamamoto, Yasuhiko, Munesue, Seiichi, Saito, Hidehito, Han, Dong, Motoyoshi, So, Kamal, Tarek, Ohara, Takuro, Watanabe, Takuo, Yamamoto, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205669/
https://www.ncbi.nlm.nih.gov/pubmed/22110482
http://dx.doi.org/10.1155/2012/894605
Descripción
Sumario:Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of the vascular injuries in diabetes. The deleterious link between RAGE and diabetic angiopathy has been demonstrated in animal studies. Preventive and therapeutic strategies focusing on RAGE and its ligand axis may be of great importance in relieving diabetic vascular complications and reducing the burden of disease.

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