Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications

Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of th...

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Autores principales: Win, Myat Thu Thu, Yamamoto, Yasuhiko, Munesue, Seiichi, Saito, Hidehito, Han, Dong, Motoyoshi, So, Kamal, Tarek, Ohara, Takuro, Watanabe, Takuo, Yamamoto, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205669/
https://www.ncbi.nlm.nih.gov/pubmed/22110482
http://dx.doi.org/10.1155/2012/894605
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author Win, Myat Thu Thu
Yamamoto, Yasuhiko
Munesue, Seiichi
Saito, Hidehito
Han, Dong
Motoyoshi, So
Kamal, Tarek
Ohara, Takuro
Watanabe, Takuo
Yamamoto, Hiroshi
author_facet Win, Myat Thu Thu
Yamamoto, Yasuhiko
Munesue, Seiichi
Saito, Hidehito
Han, Dong
Motoyoshi, So
Kamal, Tarek
Ohara, Takuro
Watanabe, Takuo
Yamamoto, Hiroshi
author_sort Win, Myat Thu Thu
collection PubMed
description Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of the vascular injuries in diabetes. The deleterious link between RAGE and diabetic angiopathy has been demonstrated in animal studies. Preventive and therapeutic strategies focusing on RAGE and its ligand axis may be of great importance in relieving diabetic vascular complications and reducing the burden of disease.
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spelling pubmed-32056692011-11-22 Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications Win, Myat Thu Thu Yamamoto, Yasuhiko Munesue, Seiichi Saito, Hidehito Han, Dong Motoyoshi, So Kamal, Tarek Ohara, Takuro Watanabe, Takuo Yamamoto, Hiroshi Exp Diabetes Res Review Article Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of the vascular injuries in diabetes. The deleterious link between RAGE and diabetic angiopathy has been demonstrated in animal studies. Preventive and therapeutic strategies focusing on RAGE and its ligand axis may be of great importance in relieving diabetic vascular complications and reducing the burden of disease. Hindawi Publishing Corporation 2012 2011-10-29 /pmc/articles/PMC3205669/ /pubmed/22110482 http://dx.doi.org/10.1155/2012/894605 Text en Copyright © 2012 Myat Thu Thu Win et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Win, Myat Thu Thu
Yamamoto, Yasuhiko
Munesue, Seiichi
Saito, Hidehito
Han, Dong
Motoyoshi, So
Kamal, Tarek
Ohara, Takuro
Watanabe, Takuo
Yamamoto, Hiroshi
Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications
title Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications
title_full Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications
title_fullStr Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications
title_full_unstemmed Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications
title_short Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications
title_sort regulation of rage for attenuating progression of diabetic vascular complications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205669/
https://www.ncbi.nlm.nih.gov/pubmed/22110482
http://dx.doi.org/10.1155/2012/894605
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