Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes

LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Co...

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Autores principales: Zhang, Min, Zhao, Hai-Ming, Qin, Zhen-Ying, Qin, Rui, Chen, Xiao-Hui, Zhao, Ya-Ping, Zhang, Chun-Mei, Gao, Chun-Lin, Zhu, Chun, Ji, Chen-Bo, Cao, Xin-Guo, Guo, Xi-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205718/
https://www.ncbi.nlm.nih.gov/pubmed/22110480
http://dx.doi.org/10.1155/2012/820989
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author Zhang, Min
Zhao, Hai-Ming
Qin, Zhen-Ying
Qin, Rui
Chen, Xiao-Hui
Zhao, Ya-Ping
Zhang, Chun-Mei
Gao, Chun-Lin
Zhu, Chun
Ji, Chen-Bo
Cao, Xin-Guo
Guo, Xi-Rong
author_facet Zhang, Min
Zhao, Hai-Ming
Qin, Zhen-Ying
Qin, Rui
Chen, Xiao-Hui
Zhao, Ya-Ping
Zhang, Chun-Mei
Gao, Chun-Lin
Zhu, Chun
Ji, Chen-Bo
Cao, Xin-Guo
Guo, Xi-Rong
author_sort Zhang, Min
collection PubMed
description LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance.
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spelling pubmed-32057182011-11-22 Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes Zhang, Min Zhao, Hai-Ming Qin, Zhen-Ying Qin, Rui Chen, Xiao-Hui Zhao, Ya-Ping Zhang, Chun-Mei Gao, Chun-Lin Zhu, Chun Ji, Chen-Bo Cao, Xin-Guo Guo, Xi-Rong Exp Diabetes Res Research Article LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance. Hindawi Publishing Corporation 2012 2011-10-26 /pmc/articles/PMC3205718/ /pubmed/22110480 http://dx.doi.org/10.1155/2012/820989 Text en Copyright © 2012 Min Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Min
Zhao, Hai-Ming
Qin, Zhen-Ying
Qin, Rui
Chen, Xiao-Hui
Zhao, Ya-Ping
Zhang, Chun-Mei
Gao, Chun-Lin
Zhu, Chun
Ji, Chen-Bo
Cao, Xin-Guo
Guo, Xi-Rong
Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes
title Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes
title_full Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes
title_fullStr Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes
title_full_unstemmed Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes
title_short Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes
title_sort regulation of lyrm1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3t3-l1 adipocytes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205718/
https://www.ncbi.nlm.nih.gov/pubmed/22110480
http://dx.doi.org/10.1155/2012/820989
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