Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudo...

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Autores principales: Fretzayas, Andrew, Liapi, Olga, Papadopoulou, Anna, Nicolaidou, Polyxeni, Stamoulakatou, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205720/
https://www.ncbi.nlm.nih.gov/pubmed/22110515
http://dx.doi.org/10.1155/2011/730250
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author Fretzayas, Andrew
Liapi, Olga
Papadopoulou, Anna
Nicolaidou, Polyxeni
Stamoulakatou, Alexandra
author_facet Fretzayas, Andrew
Liapi, Olga
Papadopoulou, Anna
Nicolaidou, Polyxeni
Stamoulakatou, Alexandra
author_sort Fretzayas, Andrew
collection PubMed
description Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudolithiasis, who were also carriers of the A(TA)(7)TAA polymorphism of the UGT1A1 gene, implying that a cause and effect relation may exist.
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spelling pubmed-32057202011-11-22 Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms? Fretzayas, Andrew Liapi, Olga Papadopoulou, Anna Nicolaidou, Polyxeni Stamoulakatou, Alexandra Case Rep Med Case Report Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudolithiasis, who were also carriers of the A(TA)(7)TAA polymorphism of the UGT1A1 gene, implying that a cause and effect relation may exist. Hindawi Publishing Corporation 2011 2011-10-26 /pmc/articles/PMC3205720/ /pubmed/22110515 http://dx.doi.org/10.1155/2011/730250 Text en Copyright © 2011 Andrew Fretzayas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Fretzayas, Andrew
Liapi, Olga
Papadopoulou, Anna
Nicolaidou, Polyxeni
Stamoulakatou, Alexandra
Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_full Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_fullStr Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_full_unstemmed Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_short Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_sort is ceftriaxone-induced biliary pseudolithiasis influenced by udp-glucuronosyltransferase 1a1 gene polymorphisms?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205720/
https://www.ncbi.nlm.nih.gov/pubmed/22110515
http://dx.doi.org/10.1155/2011/730250
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