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Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment

Castleman disease (CD) is a rare atypical lymphoproliferative disease, pathologically classified as hyaline vascular, plasma cell type and mixed type variant. The underlying cause of CD is unknown, however several theories including autoimmunity have been proposed. We describe a patient diagnosed wi...

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Autores principales: Akosman, Cengiz, Selcuk, Nalan Alan, Ordu, Cetin, Ercan, Sina, Ekici, Isin Dogan, Oyan, Basak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: e-Med 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205753/
https://www.ncbi.nlm.nih.gov/pubmed/21684830
http://dx.doi.org/10.1102/1470-7330.2011.0011
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author Akosman, Cengiz
Selcuk, Nalan Alan
Ordu, Cetin
Ercan, Sina
Ekici, Isin Dogan
Oyan, Basak
author_facet Akosman, Cengiz
Selcuk, Nalan Alan
Ordu, Cetin
Ercan, Sina
Ekici, Isin Dogan
Oyan, Basak
author_sort Akosman, Cengiz
collection PubMed
description Castleman disease (CD) is a rare atypical lymphoproliferative disease, pathologically classified as hyaline vascular, plasma cell type and mixed type variant. The underlying cause of CD is unknown, however several theories including autoimmunity have been proposed. We describe a patient diagnosed with unicentric mixed variant CD and Hashimoto thyroiditis, concurrently. She was staged with fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) and the disease was localized to the mediastinum. After 6 cycles of chemotherapy consisting of vincristine and prednisone, the mediastinal lymph nodes regressed, but did not disappear from the CT scan. However, FDG-PET/CT showed complete metabolic response. Although the role of FDG-PET/CT in staging and evaluation of treatment response is controversial, this case shows that PET/CT can be effective and even better for staging and response evaluation. This case is also unique as there no case of CD in association with Hashimoto thyroiditis has been reported previously. However, the possibility of a coincidental association must be raised, especially when the high prevalence of Hashimoto thyroiditis is considered.
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spelling pubmed-32057532013-06-15 Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment Akosman, Cengiz Selcuk, Nalan Alan Ordu, Cetin Ercan, Sina Ekici, Isin Dogan Oyan, Basak Cancer Imaging Case Report Castleman disease (CD) is a rare atypical lymphoproliferative disease, pathologically classified as hyaline vascular, plasma cell type and mixed type variant. The underlying cause of CD is unknown, however several theories including autoimmunity have been proposed. We describe a patient diagnosed with unicentric mixed variant CD and Hashimoto thyroiditis, concurrently. She was staged with fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) and the disease was localized to the mediastinum. After 6 cycles of chemotherapy consisting of vincristine and prednisone, the mediastinal lymph nodes regressed, but did not disappear from the CT scan. However, FDG-PET/CT showed complete metabolic response. Although the role of FDG-PET/CT in staging and evaluation of treatment response is controversial, this case shows that PET/CT can be effective and even better for staging and response evaluation. This case is also unique as there no case of CD in association with Hashimoto thyroiditis has been reported previously. However, the possibility of a coincidental association must be raised, especially when the high prevalence of Hashimoto thyroiditis is considered. e-Med 2011-06-15 /pmc/articles/PMC3205753/ /pubmed/21684830 http://dx.doi.org/10.1102/1470-7330.2011.0011 Text en © 2011 International Cancer Imaging Society
spellingShingle Case Report
Akosman, Cengiz
Selcuk, Nalan Alan
Ordu, Cetin
Ercan, Sina
Ekici, Isin Dogan
Oyan, Basak
Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_full Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_fullStr Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_full_unstemmed Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_short Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_sort unicentric mixed variant castleman disease associated with hashimoto disease: the role of pet/ct in staging and evaluating response to the treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205753/
https://www.ncbi.nlm.nih.gov/pubmed/21684830
http://dx.doi.org/10.1102/1470-7330.2011.0011
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